Insulin-related materials in the nervous system of vertebrates and non-vertebrates: Possible extrapancreatic production

D. LeRoith, M. Adamo, J. Shemer, R. Waldbillig, M. A. Lesniak, F. DePablo, C. Hart, J. Roth

Research output: Contribution to journalReview article

24 Scopus citations

Abstract

Studies from multiple laboratories with a range of methods raised the possibility that insulin production occurs naturally at extrapancreatic sites. Part A covers the presence of insulin-related materials in organisms that do not have an endocrine pancreas, including unicellular prokaryotes and eukaryotes as well as multicellular non-vertebrate animals (insects et al.) and plants. Part B covers possible production of insulin by extrapancreatic tissues of vertebrates that are remote from a source of pancreatic insulin e.g. early chick embryos and mammalian cells in cultures. Part C covers possible extrapancreatic insulin production in mammals in vivo. Each section ends with an outline summary with evidence in favor of and against the hypothesis.

Original languageEnglish (US)
Pages (from-to)411-420
Number of pages10
JournalHormone and Metabolic Research
Volume20
Issue number7
StatePublished - Jan 1 1988
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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    LeRoith, D., Adamo, M., Shemer, J., Waldbillig, R., Lesniak, M. A., DePablo, F., Hart, C., & Roth, J. (1988). Insulin-related materials in the nervous system of vertebrates and non-vertebrates: Possible extrapancreatic production. Hormone and Metabolic Research, 20(7), 411-420.