Insulin-like growth factors

Derek Leroith, Michelle McGuinness, Joshua Shemer, Bethel Stannard, Fabienne Lanau, Teresa N. Faria, Hisanori Kato, Haim Werner, Martin L Adamo, Charles T. Robert

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

The insulin-like growth factors (IGF-I and IGF-II) play important roles in the regulation of growth and metabolism. While the liver is the main source of circulating IGFs, their production by numerous extrahepatic tissues suggests the existence of autocrine and paracrine modes of action in addition to typical endocrine mechanisms. The actions of the IGFs are mediated through their activation of specific cell surface receptors, primarily the IGF-I receptor, although some effects may be mediated through the IGF-II receptor and the insulin receptor. The stability of the IGFs and their interaction with their receptors are mediated by specific IGF binding proteins (IGF-BPs) which are found in the circulation and in extracellular fluids. Thus, the overall biological actions of the IGFs can be regulated by control of ligand biosynthesis, modulation of receptor levels and postreceptor signalling pathways, and changes in the levels and activity of IGF-BPs.

Original languageEnglish (US)
Pages (from-to)173-181
Number of pages9
JournalNeuroSignals
Volume1
Issue number4
DOIs
StatePublished - 1992
Externally publishedYes

Keywords

  • Gene expression
  • Gene structure
  • Growth factors
  • IGF receptors
  • IGF-binding proteins
  • IGF-I
  • IGF-II
  • Signal transduction

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Developmental Neuroscience
  • Neurology

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