Insulin-induced attenuation of glucose-stimulated gastric inhibitory polypeptide secretion

Kenneth R. Sirinek, William G. Pace, Samuel E. Crockett, Thomas M. O'Dorisio, Ernest L. Mazzaferri, Samuel Cataland

Research output: Contribution to journalArticle

18 Scopus citations


Administration of exogenous insulin before and after intraduodenal glucose results in blunting of the GIP response to glucose. Physiologic levels of serum insulin were attained. Therefore, the present study suggests the existence of negative feedback regulation of GIP release by endogenous insulin (pancreatico-GIP axis).

Original languageEnglish (US)
Pages (from-to)151-155
Number of pages5
JournalThe American Journal of Surgery
Issue number2
Publication statusPublished - Feb 1978


ASJC Scopus subject areas

  • Surgery

Cite this