Insulin clearance and the incidence of type 2 diabetes in hispanics and African Americans: The IRAS family study

C. Christine Lee, Steven M. Haffner, Lynne E. Wagenknecht, Carlos Lorenzo, Jill M. Norris, Richard N. Bergman, Darko Stefanovski, Andrea M. Anderson, Jerome I. Rotter, Mark O. Goodarzi, Anthony J. Hanley

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Abstract

OBJECTIVE-We aimed to identify factors that are independently associated with the metabolic clearance rate of insulin (MCRI) and to examine the association ofMCRI with incident type 2 diabetes in nondiabetic Hispanics and African Americans. RESEARCH DESIGN AND METHODS-We investigated 1,116 participants in the Insulin Resistance Atherosclerosis Study (IRAS) Family Study with baseline examinations from 2000 to 2002 and follow-up examinations from 2005 to 2006. Insulin sensitivity (SI), acute insulin response (AIR), and MCRI were determined at baseline from frequently sampled intravenous glucose tolerance tests. MCRI was calculated as the ratio of the insulin dose over the incremental area under the curve of insulin. Incident diabetes was defined as fasting glucose ≥126 mg/dL or antidiabetic medication use by self-report. RESULTS-We observed that SI and HDL cholesterol were independent positive correlates of MCRI, whereas fasting insulin, fasting glucose, subcutaneous adipose tissue, visceral adipose tissue, and AIR were independent negative correlates (all P < 0.05) at baseline. After 5 years of follow-up, 71 (6.4%) participants developed type 2 diabetes. Lower MCRI was associated with a higher risk of incident diabetes after adjusting for demographics, lifestyle factors, HDL cholesterol, indexes of obesity and adiposity, and insulin secretion (odds ratio 2.01 [95% CI 1.30- 3.10], P = 0.0064, per one-SD decrease in loge-transformed MCRI). CONCLUSIONS-Our data showed that lower MCRI predicts the incidence of type 2 diabetes.

Original languageEnglish (US)
Pages (from-to)901-907
Number of pages7
JournalDiabetes Care
Volume36
Issue number4
DOIs
StatePublished - Apr 2013

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Hispanic Americans
African Americans
Type 2 Diabetes Mellitus
Insulin Resistance
Atherosclerosis
Metabolic Clearance Rate
Insulin
Incidence
Fasting
HDL Cholesterol
Glucose
Intra-Abdominal Fat
Subcutaneous Fat
Adiposity
Glucose Tolerance Test
Hypoglycemic Agents
Self Report
Area Under Curve
Life Style
Research Design

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

Cite this

Lee, C. C., Haffner, S. M., Wagenknecht, L. E., Lorenzo, C., Norris, J. M., Bergman, R. N., ... Hanley, A. J. (2013). Insulin clearance and the incidence of type 2 diabetes in hispanics and African Americans: The IRAS family study. Diabetes Care, 36(4), 901-907. https://doi.org/10.2337/dc12-1316

Insulin clearance and the incidence of type 2 diabetes in hispanics and African Americans : The IRAS family study. / Lee, C. Christine; Haffner, Steven M.; Wagenknecht, Lynne E.; Lorenzo, Carlos; Norris, Jill M.; Bergman, Richard N.; Stefanovski, Darko; Anderson, Andrea M.; Rotter, Jerome I.; Goodarzi, Mark O.; Hanley, Anthony J.

In: Diabetes Care, Vol. 36, No. 4, 04.2013, p. 901-907.

Research output: Contribution to journalArticle

Lee, CC, Haffner, SM, Wagenknecht, LE, Lorenzo, C, Norris, JM, Bergman, RN, Stefanovski, D, Anderson, AM, Rotter, JI, Goodarzi, MO & Hanley, AJ 2013, 'Insulin clearance and the incidence of type 2 diabetes in hispanics and African Americans: The IRAS family study', Diabetes Care, vol. 36, no. 4, pp. 901-907. https://doi.org/10.2337/dc12-1316
Lee, C. Christine ; Haffner, Steven M. ; Wagenknecht, Lynne E. ; Lorenzo, Carlos ; Norris, Jill M. ; Bergman, Richard N. ; Stefanovski, Darko ; Anderson, Andrea M. ; Rotter, Jerome I. ; Goodarzi, Mark O. ; Hanley, Anthony J. / Insulin clearance and the incidence of type 2 diabetes in hispanics and African Americans : The IRAS family study. In: Diabetes Care. 2013 ; Vol. 36, No. 4. pp. 901-907.
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AU - Norris, Jill M.

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