Insulin and renal sodium handling

Clinical implications

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

Over the last ten years a large body of information has accumulated which indicates that physiologic changes in the plasma insulin concentration are capable of affecting electrolyte transport by the kidney as well as by a variety of other tissues. In the present discussion the effect of insulin on the renal handling of sodium, potassium, phosphate, and calcium is reviewed, with an emphasis on sodium transport. An attempt is made to relate the effects of insulin on sodium metabolism to four common clinical situations: hypertension and obesity, sodium wasting in diabetes mellitus, natriuresis of starvation, and sodium retention and edema following refeeding.

Original languageEnglish (US)
Pages (from-to)93-104
Number of pages12
JournalInternational Journal of Obesity
Volume5
Issue numberSuppl. 1
StatePublished - 1981
Externally publishedYes

Fingerprint

insulin
Sodium
kidneys
sodium
Insulin
Kidney
Natriuresis
Starvation
Electrolytes
Edema
Diabetes Mellitus
potassium phosphates
Obesity
refeeding
Hypertension
Calcium
diabetes mellitus
edema
hypertension
electrolytes

ASJC Scopus subject areas

  • Food Science
  • Endocrinology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Public Health, Environmental and Occupational Health

Cite this

Insulin and renal sodium handling : Clinical implications. / Defronzo, Ralph A.

In: International Journal of Obesity, Vol. 5, No. Suppl. 1, 1981, p. 93-104.

Research output: Contribution to journalArticle

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