Abstract
Right hemisphere dysfunction is associated with mortality in Alzheimer's disease (AD) and other neurologic conditions. These associations may be mediated by insular pathology, as insular lesions result in demonstrable changes in cardiovascular and autonomic control. AD affects the insulae at a preclinical stage, and insular AD pathology may be present in up to 40% of nondemented septuagenarians and octogenarians. This pathology can affect in vivo cardiac conduction and thereby dispose to cardiac arrhythmias and sudden death. Thus, AD pathology should be considered as a possible explanation for autonomic morbidity and mortality in nondemented elderly persons.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 97-99 |
| Number of pages | 3 |
| Journal | Cleveland Clinic Journal of Medicine |
| Volume | 75 |
| Issue number | SUPPL.2 |
| State | Published - 2008 |
Fingerprint
ASJC Scopus subject areas
- Medicine(all)
Cite this
Insular Alzheimer disease pathology and the psychometric correlates of mortality. / Royall, Donald R.
In: Cleveland Clinic Journal of Medicine, Vol. 75, No. SUPPL.2, 2008, p. 97-99.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Insular Alzheimer disease pathology and the psychometric correlates of mortality
AU - Royall, Donald R
PY - 2008
Y1 - 2008
N2 - Right hemisphere dysfunction is associated with mortality in Alzheimer's disease (AD) and other neurologic conditions. These associations may be mediated by insular pathology, as insular lesions result in demonstrable changes in cardiovascular and autonomic control. AD affects the insulae at a preclinical stage, and insular AD pathology may be present in up to 40% of nondemented septuagenarians and octogenarians. This pathology can affect in vivo cardiac conduction and thereby dispose to cardiac arrhythmias and sudden death. Thus, AD pathology should be considered as a possible explanation for autonomic morbidity and mortality in nondemented elderly persons.
AB - Right hemisphere dysfunction is associated with mortality in Alzheimer's disease (AD) and other neurologic conditions. These associations may be mediated by insular pathology, as insular lesions result in demonstrable changes in cardiovascular and autonomic control. AD affects the insulae at a preclinical stage, and insular AD pathology may be present in up to 40% of nondemented septuagenarians and octogenarians. This pathology can affect in vivo cardiac conduction and thereby dispose to cardiac arrhythmias and sudden death. Thus, AD pathology should be considered as a possible explanation for autonomic morbidity and mortality in nondemented elderly persons.
UR - http://www.scopus.com/inward/record.url?scp=47249161497&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=47249161497&partnerID=8YFLogxK
M3 - Article
C2 - 18540156
AN - SCOPUS:47249161497
VL - 75
SP - 97
EP - 99
JO - Cleveland Clinic Journal of Medicine
JF - Cleveland Clinic Journal of Medicine
SN - 0891-1150
IS - SUPPL.2
ER -