Insights into inflammation and epilepsy from the basic and clinical sciences

Gustavo Silveira, Antonio Carlos Pinheiro De Oliveira, Antonio Lucio Teixeira

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations

Abstract

Inflammatory mediators are overexpressed in brain tissue after induction of seizures in animal models, and several studies demonstrate their involvement in neuronal hyperexcitability, seizure frequency and duration. In accordance with these results, the study of cerebrospinal fluid and brain specimens from patients with chronic epilepsy have shown increased levels of cytokines and areas of hippocampal sclerosis, respectively. Here we review the current findings supporting the existence of an ongoing inflammatory process in the physiopathology of epilepsy.

Original languageEnglish (US)
Pages (from-to)1071-1075
Number of pages5
JournalJournal of Clinical Neuroscience
Volume19
Issue number8
DOIs
StatePublished - Aug 2012
Externally publishedYes

Keywords

  • Cytokines
  • Epilepsy
  • Immunology
  • Inflammation

ASJC Scopus subject areas

  • Surgery
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

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