Insensitivity of the reproductive system of pinealectomized superior cervical ganglionectomized male Syrian hamsters to twice daily injections of melatonin

B. N. Joshi, M. K. Vaughan, R. J. Reiter

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

The reproductive responses to twice daily melatonin injections were studied in intact, pinealectomized (PINX), superior cervical ganglionectomized (SCGX), and in PINX + SCGX male hamsters. A significant drop in testicular and accessory organ weights, plasma testosterone (T) and thyroxine (T4) ensued in the intact, PINX and SCGX animals. In PINX + SCGX hamsters, although the testicular weights were slightly reduced, the accessory organ weights, plasma T and T4 levels remained unchanged. The results suggest that both pineal and the superior cervical ganglia may mediate melatonin-induced reproductive collapse. Both the pineal and the ganglia could be target organs for melatonin.

Original languageEnglish (US)
Pages (from-to)191-195
Number of pages5
JournalNeuroendocrinology Letters
Volume7
Issue number4
StatePublished - Jan 1 1985

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Neurology
  • Endocrine and Autonomic Systems
  • Clinical Neurology
  • Psychiatry and Mental health

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