Injections of α-melanocyte stimulating hormone affect pineal serotonin, melatonin and N-acetyltransferase activity

Sol Oaknin; Mary K. Vaughan; Maureen E. Troiani; George M. Vaughan; Russel J. Reiter

doi:10.1016/0742-8413(87)90137-X

Injections of α-melanocyte stimulating hormone affect pineal serotonin, melatonin and N-acetyltransferase activity

Sol Oaknin, Mary K. Vaughan, Maureen E. Troiani, George M. Vaughan, Russel J. Reiter

Department of Cell Systems & Anatomy

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

1. To determine if exogenously administered α-melanocyte stimulating hormone (α-MSH) affects nighttime pineal N-acetyltransferase activity, pineal levels of 5-hydroxytryptophan, serotonin and melatonin, and plasma prolactin levels, adult male hamsters were injected at 1900hr (lights out 2000-0600 hr) with two doses of the peptide and killed at 0300 hr. 2. The low dose of α-MSH (200 ng) produced a significant fall in pineal serotonin, pineal NAT activity and plasma prolactin values. 3. The high dose of the peptide (20 μg) increased circulating prolactin titers and pineal serotonin levels and caused a concomitant decrease in pineal melatonin levels.

Original language	English (US)
Pages (from-to)	23-26
Number of pages	4
Journal	Comparative Biochemistry and Physiology. Part C, Comparative
Volume	86
Issue number	1
DOIs	https://doi.org/10.1016/0742-8413(87)90137-X
State	Published - 1987

ASJC Scopus subject areas

Pharmacology
Immunology

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@article{d0ededcfc28f46ea8ef92038b0be83bc,

title = "Injections of α-melanocyte stimulating hormone affect pineal serotonin, melatonin and N-acetyltransferase activity",

abstract = "1. To determine if exogenously administered α-melanocyte stimulating hormone (α-MSH) affects nighttime pineal N-acetyltransferase activity, pineal levels of 5-hydroxytryptophan, serotonin and melatonin, and plasma prolactin levels, adult male hamsters were injected at 1900hr (lights out 2000-0600 hr) with two doses of the peptide and killed at 0300 hr. 2. The low dose of α-MSH (200 ng) produced a significant fall in pineal serotonin, pineal NAT activity and plasma prolactin values. 3. The high dose of the peptide (20 μg) increased circulating prolactin titers and pineal serotonin levels and caused a concomitant decrease in pineal melatonin levels.",

author = "Sol Oaknin and Vaughan, {Mary K.} and Troiani, {Maureen E.} and Vaughan, {George M.} and Reiter, {Russel J.}",

note = "Funding Information: Ackr:.l~/edRpments~This work was supported by CCA-841106 and CCA-8309108 from the US-Spain Joint Committee for Scientific and Technological Cooperation. Dr Sol Oaknin was supported by Caja Ahorros de Tenerife---La Laguna University.",

year = "1987",

doi = "10.1016/0742-8413(87)90137-X",

language = "English (US)",

volume = "86",

pages = "23--26",

journal = "Comparative Biochemistry and Physiology. Part C, Comparative",

issn = "0306-4492",

publisher = "Elsevier B.V.",

number = "1",

}

TY - JOUR

T1 - Injections of α-melanocyte stimulating hormone affect pineal serotonin, melatonin and N-acetyltransferase activity

AU - Oaknin, Sol

AU - Vaughan, Mary K.

AU - Troiani, Maureen E.

AU - Vaughan, George M.

AU - Reiter, Russel J.

N1 - Funding Information: Ackr:.l~/edRpments~This work was supported by CCA-841106 and CCA-8309108 from the US-Spain Joint Committee for Scientific and Technological Cooperation. Dr Sol Oaknin was supported by Caja Ahorros de Tenerife---La Laguna University.

PY - 1987

Y1 - 1987

N2 - 1. To determine if exogenously administered α-melanocyte stimulating hormone (α-MSH) affects nighttime pineal N-acetyltransferase activity, pineal levels of 5-hydroxytryptophan, serotonin and melatonin, and plasma prolactin levels, adult male hamsters were injected at 1900hr (lights out 2000-0600 hr) with two doses of the peptide and killed at 0300 hr. 2. The low dose of α-MSH (200 ng) produced a significant fall in pineal serotonin, pineal NAT activity and plasma prolactin values. 3. The high dose of the peptide (20 μg) increased circulating prolactin titers and pineal serotonin levels and caused a concomitant decrease in pineal melatonin levels.

AB - 1. To determine if exogenously administered α-melanocyte stimulating hormone (α-MSH) affects nighttime pineal N-acetyltransferase activity, pineal levels of 5-hydroxytryptophan, serotonin and melatonin, and plasma prolactin levels, adult male hamsters were injected at 1900hr (lights out 2000-0600 hr) with two doses of the peptide and killed at 0300 hr. 2. The low dose of α-MSH (200 ng) produced a significant fall in pineal serotonin, pineal NAT activity and plasma prolactin values. 3. The high dose of the peptide (20 μg) increased circulating prolactin titers and pineal serotonin levels and caused a concomitant decrease in pineal melatonin levels.

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U2 - 10.1016/0742-8413(87)90137-X

DO - 10.1016/0742-8413(87)90137-X

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AN - SCOPUS:0023089156

SN - 0306-4492

VL - 86

SP - 23

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JO - Comparative Biochemistry and Physiology. Part C, Comparative

JF - Comparative Biochemistry and Physiology. Part C, Comparative

IS - 1

ER -

Injections of α-melanocyte stimulating hormone affect pineal serotonin, melatonin and N-acetyltransferase activity

Abstract

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