Injections of α-melanocyte stimulating hormone affect pineal serotonin, melatonin and N-acetyltransferase activity

Sol Oaknin, Mary K. Vaughan, Maureen E. Troiani, George M. Vaughan, Russel J. Reiter

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

1. To determine if exogenously administered α-melanocyte stimulating hormone (α-MSH) affects nighttime pineal N-acetyltransferase activity, pineal levels of 5-hydroxytryptophan, serotonin and melatonin, and plasma prolactin levels, adult male hamsters were injected at 1900hr (lights out 2000-0600 hr) with two doses of the peptide and killed at 0300 hr. 2. The low dose of α-MSH (200 ng) produced a significant fall in pineal serotonin, pineal NAT activity and plasma prolactin values. 3. The high dose of the peptide (20 μg) increased circulating prolactin titers and pineal serotonin levels and caused a concomitant decrease in pineal melatonin levels.

Original languageEnglish (US)
Pages (from-to)23-26
Number of pages4
JournalComparative Biochemistry and Physiology. Part C, Comparative
Volume86
Issue number1
DOIs
StatePublished - 1987

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

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