Initiation, promotion and complete carcinogenesis by N-methyl-N′-nitro-N-nitrosoguanidine or ethylnitrosourea in the Sencar mouse skin tumorigenesis model

John F. O'Connell; Stephen Nesnow; Thomas J. Slaga

doi:10.1016/0304-3835(87)90115-7

Initiation, promotion and complete carcinogenesis by N-methyl-N′-nitro-N-nitrosoguanidine or ethylnitrosourea in the Sencar mouse skin tumorigenesis model

John F. O'Connell, Stephen Nesnow, Thomas J. Slaga

Research output: Contribution to journal › Article › peer-review

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Abstract

Five doses of either N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) or ethylnitrosourea (ENU) were tested as complete carcinogens, tumor initiators and tumor promoters in the SENCAR skin tumorigenesis model. As tumor initiators, MNNG-induced papillomas at all doses tested, while ENU was active from 10-40 μmol. As complete carcinogens, MNNG from doses of 0.5-5.0 μmol and ENU from doses of 10 μmol-40 μmol were potent inducers of both papillomas and carcinomas indicating that these agents are active as both tumor initiators and tumor promoters.

Original language	English (US)
Pages (from-to)	301-310
Number of pages	10
Journal	Cancer Letters
Volume	37
Issue number	3
DOIs	https://doi.org/10.1016/0304-3835(87)90115-7
State	Published - Nov 1987
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

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title = "Initiation, promotion and complete carcinogenesis by N-methyl-N′-nitro-N-nitrosoguanidine or ethylnitrosourea in the Sencar mouse skin tumorigenesis model",

abstract = "Five doses of either N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) or ethylnitrosourea (ENU) were tested as complete carcinogens, tumor initiators and tumor promoters in the SENCAR skin tumorigenesis model. As tumor initiators, MNNG-induced papillomas at all doses tested, while ENU was active from 10-40 μmol. As complete carcinogens, MNNG from doses of 0.5-5.0 μmol and ENU from doses of 10 μmol-40 μmol were potent inducers of both papillomas and carcinomas indicating that these agents are active as both tumor initiators and tumor promoters.",

author = "O'Connell, {John F.} and Stephen Nesnow and Slaga, {Thomas J.}",

note = "Funding Information: Supported by the U.S. Environmental Protection Agency contract 79DX0526. We gratefully acknowledge the helpful assistance of Christie Hoy, Karen Engel, Catherine Veninga, John Riley and Judy Ing in the preparation of this manuscript.",

year = "1987",

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doi = "10.1016/0304-3835(87)90115-7",

language = "English (US)",

volume = "37",

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journal = "Cancer Letters",

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T1 - Initiation, promotion and complete carcinogenesis by N-methyl-N′-nitro-N-nitrosoguanidine or ethylnitrosourea in the Sencar mouse skin tumorigenesis model

AU - O'Connell, John F.

AU - Nesnow, Stephen

AU - Slaga, Thomas J.

N1 - Funding Information: Supported by the U.S. Environmental Protection Agency contract 79DX0526. We gratefully acknowledge the helpful assistance of Christie Hoy, Karen Engel, Catherine Veninga, John Riley and Judy Ing in the preparation of this manuscript.

PY - 1987/11

Y1 - 1987/11

N2 - Five doses of either N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) or ethylnitrosourea (ENU) were tested as complete carcinogens, tumor initiators and tumor promoters in the SENCAR skin tumorigenesis model. As tumor initiators, MNNG-induced papillomas at all doses tested, while ENU was active from 10-40 μmol. As complete carcinogens, MNNG from doses of 0.5-5.0 μmol and ENU from doses of 10 μmol-40 μmol were potent inducers of both papillomas and carcinomas indicating that these agents are active as both tumor initiators and tumor promoters.

AB - Five doses of either N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) or ethylnitrosourea (ENU) were tested as complete carcinogens, tumor initiators and tumor promoters in the SENCAR skin tumorigenesis model. As tumor initiators, MNNG-induced papillomas at all doses tested, while ENU was active from 10-40 μmol. As complete carcinogens, MNNG from doses of 0.5-5.0 μmol and ENU from doses of 10 μmol-40 μmol were potent inducers of both papillomas and carcinomas indicating that these agents are active as both tumor initiators and tumor promoters.

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Initiation, promotion and complete carcinogenesis by N-methyl-N′-nitro-N-nitrosoguanidine or ethylnitrosourea in the Sencar mouse skin tumorigenesis model

Abstract

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