Initiation, promotion and complete carcinogenesis by N-methyl-N′-nitro-N-nitrosoguanidine or ethylnitrosourea in the Sencar mouse skin tumorigenesis model

John F. O'Connell, Stephen Nesnow, Thomas J. Slaga

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Five doses of either N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) or ethylnitrosourea (ENU) were tested as complete carcinogens, tumor initiators and tumor promoters in the SENCAR skin tumorigenesis model. As tumor initiators, MNNG-induced papillomas at all doses tested, while ENU was active from 10-40 μmol. As complete carcinogens, MNNG from doses of 0.5-5.0 μmol and ENU from doses of 10 μmol-40 μmol were potent inducers of both papillomas and carcinomas indicating that these agents are active as both tumor initiators and tumor promoters.

Original languageEnglish (US)
Pages (from-to)301-310
Number of pages10
JournalCancer Letters
Volume37
Issue number3
DOIs
StatePublished - Nov 1987
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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