Five doses of either N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) or ethylnitrosourea (ENU) were tested as complete carcinogens, tumor initiators and tumor promoters in the SENCAR skin tumorigenesis model. As tumor initiators, MNNG-induced papillomas at all doses tested, while ENU was active from 10-40 μmol. As complete carcinogens, MNNG from doses of 0.5-5.0 μmol and ENU from doses of 10 μmol-40 μmol were potent inducers of both papillomas and carcinomas indicating that these agents are active as both tumor initiators and tumor promoters.
ASJC Scopus subject areas
- Cancer Research