Initiation and post-initiation chemopreventive effects of diallyl sulfide in esophageal carcinogenesis

Michael J. Wargovich, Osamu Imada, L. C. Stephens

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Abstract

Diallyl sulfide (DAS), one of a number of organosulfur compounds accounting for the flavor and smell associated with garlic, has been shown to inhibit a number of chemically induced forms of cancer. In this study, DAS was examined for its chemopreventive effects in both the initiation and post-initiation phases of nitrosomethylbenzylamine-induced esophageal carcinogenesis in the Sprague - Dawley rat. Although highly inhibitory during initiation, DAS is ineffective when given after the carcinogen. DAS, though not effective as a preventive in post-initiation, was not found to promote esophageal carcinogenesis.

Original languageEnglish (US)
Pages (from-to)39-42
Number of pages4
JournalCancer Letters
Volume64
Issue number1
DOIs
Publication statusPublished - May 30 1992

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Keywords

  • alliums
  • chemoprevention
  • diallyl sulfide
  • esophageal cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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