Initiation and post-initiation chemopreventive effects of diallyl sulfide in esophageal carcinogenesis

Michael J. Wargovich; Osamu Imada; L. C. Stephens

doi:10.1016/0304-3835(92)90019-R

Initiation and post-initiation chemopreventive effects of diallyl sulfide in esophageal carcinogenesis

Michael J. Wargovich, Osamu Imada, L. C. Stephens

Molecular Medicine

Research output: Contribution to journal › Article › peer-review

83 Scopus citations

Abstract

Diallyl sulfide (DAS), one of a number of organosulfur compounds accounting for the flavor and smell associated with garlic, has been shown to inhibit a number of chemically induced forms of cancer. In this study, DAS was examined for its chemopreventive effects in both the initiation and post-initiation phases of nitrosomethylbenzylamine-induced esophageal carcinogenesis in the Sprague - Dawley rat. Although highly inhibitory during initiation, DAS is ineffective when given after the carcinogen. DAS, though not effective as a preventive in post-initiation, was not found to promote esophageal carcinogenesis.

Original language	English (US)
Pages (from-to)	39-42
Number of pages	4
Journal	Cancer Letters
Volume	64
Issue number	1
DOIs	https://doi.org/10.1016/0304-3835(92)90019-R
State	Published - May 30 1992

Keywords

alliums
chemoprevention
diallyl sulfide
esophageal cancer

ASJC Scopus subject areas

Oncology
Cancer Research

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title = "Initiation and post-initiation chemopreventive effects of diallyl sulfide in esophageal carcinogenesis",

abstract = "Diallyl sulfide (DAS), one of a number of organosulfur compounds accounting for the flavor and smell associated with garlic, has been shown to inhibit a number of chemically induced forms of cancer. In this study, DAS was examined for its chemopreventive effects in both the initiation and post-initiation phases of nitrosomethylbenzylamine-induced esophageal carcinogenesis in the Sprague - Dawley rat. Although highly inhibitory during initiation, DAS is ineffective when given after the carcinogen. DAS, though not effective as a preventive in post-initiation, was not found to promote esophageal carcinogenesis.",

keywords = "alliums, chemoprevention, diallyl sulfide, esophageal cancer",

author = "Wargovich, {Michael J.} and Osamu Imada and Stephens, {L. C.}",

note = "Funding Information: The authors wish to recognize the expert technical assistanceo f Cindy Palmer, Marco Velasco and Teresa Joseph. The study was supported by grant 89B25 from the American Institute for Cancer Research, NC1 Cancer Center Support Grant CA-16 772 and from the Wakunaga Pharmaceutical Co, Ltd., Osaka, Japan.",

year = "1992",

month = may,

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doi = "10.1016/0304-3835(92)90019-R",

language = "English (US)",

volume = "64",

pages = "39--42",

journal = "Cancer Letters",

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number = "1",

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T1 - Initiation and post-initiation chemopreventive effects of diallyl sulfide in esophageal carcinogenesis

AU - Wargovich, Michael J.

AU - Imada, Osamu

AU - Stephens, L. C.

N1 - Funding Information: The authors wish to recognize the expert technical assistanceo f Cindy Palmer, Marco Velasco and Teresa Joseph. The study was supported by grant 89B25 from the American Institute for Cancer Research, NC1 Cancer Center Support Grant CA-16 772 and from the Wakunaga Pharmaceutical Co, Ltd., Osaka, Japan.

PY - 1992/5/30

Y1 - 1992/5/30

N2 - Diallyl sulfide (DAS), one of a number of organosulfur compounds accounting for the flavor and smell associated with garlic, has been shown to inhibit a number of chemically induced forms of cancer. In this study, DAS was examined for its chemopreventive effects in both the initiation and post-initiation phases of nitrosomethylbenzylamine-induced esophageal carcinogenesis in the Sprague - Dawley rat. Although highly inhibitory during initiation, DAS is ineffective when given after the carcinogen. DAS, though not effective as a preventive in post-initiation, was not found to promote esophageal carcinogenesis.

AB - Diallyl sulfide (DAS), one of a number of organosulfur compounds accounting for the flavor and smell associated with garlic, has been shown to inhibit a number of chemically induced forms of cancer. In this study, DAS was examined for its chemopreventive effects in both the initiation and post-initiation phases of nitrosomethylbenzylamine-induced esophageal carcinogenesis in the Sprague - Dawley rat. Although highly inhibitory during initiation, DAS is ineffective when given after the carcinogen. DAS, though not effective as a preventive in post-initiation, was not found to promote esophageal carcinogenesis.

KW - alliums

KW - chemoprevention

KW - diallyl sulfide

KW - esophageal cancer

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SP - 39

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JO - Cancer Letters

JF - Cancer Letters

SN - 0304-3835

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ER -

Initiation and post-initiation chemopreventive effects of diallyl sulfide in esophageal carcinogenesis

Abstract

Keywords

ASJC Scopus subject areas

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