Abstract
Diallyl sulfide (DAS), one of a number of organosulfur compounds accounting for the flavor and smell associated with garlic, has been shown to inhibit a number of chemically induced forms of cancer. In this study, DAS was examined for its chemopreventive effects in both the initiation and post-initiation phases of nitrosomethylbenzylamine-induced esophageal carcinogenesis in the Sprague - Dawley rat. Although highly inhibitory during initiation, DAS is ineffective when given after the carcinogen. DAS, though not effective as a preventive in post-initiation, was not found to promote esophageal carcinogenesis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 39-42 |
| Number of pages | 4 |
| Journal | Cancer Letters |
| Volume | 64 |
| Issue number | 1 |
| DOIs | |
| State | Published - May 30 1992 |
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Keywords
- alliums
- chemoprevention
- diallyl sulfide
- esophageal cancer
ASJC Scopus subject areas
- Cancer Research
- Molecular Biology
- Oncology
Cite this
Initiation and post-initiation chemopreventive effects of diallyl sulfide in esophageal carcinogenesis. / Wargovich, Michael J.; Imada, Osamu; Stephens, L. C.
In: Cancer Letters, Vol. 64, No. 1, 30.05.1992, p. 39-42.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Initiation and post-initiation chemopreventive effects of diallyl sulfide in esophageal carcinogenesis
AU - Wargovich, Michael J.
AU - Imada, Osamu
AU - Stephens, L. C.
PY - 1992/5/30
Y1 - 1992/5/30
N2 - Diallyl sulfide (DAS), one of a number of organosulfur compounds accounting for the flavor and smell associated with garlic, has been shown to inhibit a number of chemically induced forms of cancer. In this study, DAS was examined for its chemopreventive effects in both the initiation and post-initiation phases of nitrosomethylbenzylamine-induced esophageal carcinogenesis in the Sprague - Dawley rat. Although highly inhibitory during initiation, DAS is ineffective when given after the carcinogen. DAS, though not effective as a preventive in post-initiation, was not found to promote esophageal carcinogenesis.
AB - Diallyl sulfide (DAS), one of a number of organosulfur compounds accounting for the flavor and smell associated with garlic, has been shown to inhibit a number of chemically induced forms of cancer. In this study, DAS was examined for its chemopreventive effects in both the initiation and post-initiation phases of nitrosomethylbenzylamine-induced esophageal carcinogenesis in the Sprague - Dawley rat. Although highly inhibitory during initiation, DAS is ineffective when given after the carcinogen. DAS, though not effective as a preventive in post-initiation, was not found to promote esophageal carcinogenesis.
KW - alliums
KW - chemoprevention
KW - diallyl sulfide
KW - esophageal cancer
UR - http://www.scopus.com/inward/record.url?scp=0026780968&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026780968&partnerID=8YFLogxK
U2 - 10.1016/0304-3835(92)90019-R
DO - 10.1016/0304-3835(92)90019-R
M3 - Article
C2 - 1596875
AN - SCOPUS:0026780968
VL - 64
SP - 39
EP - 42
JO - Cancer Letters
JF - Cancer Letters
SN - 0304-3835
IS - 1
ER -