Initial testing (stage 1) of the topoisomerase II inhibitor pixantrone, by the pediatric preclinical testing program

Raushan T. Kurmasheva; C. Patrick Reynolds; Min H. Kang; Cecilia Allievi; Peter J. Houghton; Malcolm A. Smith

doi:10.1002/pbc.24800

Initial testing (stage 1) of the topoisomerase II inhibitor pixantrone, by the pediatric preclinical testing program

Raushan T. Kurmasheva
, C. Patrick Reynolds
, Min H. Kang
, Cecilia Allievi
, Peter J. Houghton
, Malcolm A. Smith

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Pixantrone, a novel aza-anthracenedione with cytotoxic activity, was tested against the PPTP in vitro panel (3.0nM to 30.0μM) and against a limited panel of PPTP Wilms tumors and sarcomas (7.5mg/kg) administered intravenously using an every 4 day×3 schedule. In vitro pixantrone showed a median relative IC₅₀ value of 54nM (range <3nM to 1.03μM). In vivo pixantrone induced significant differences in EFS distribution compared to controls in two of eight solid tumor xenografts at dose levels relevant to human drug exposure. A complete response was observed for one Wilms tumor xenograft. Pediatr Blood Cancer 2014;61:922-924.

Original language	English (US)
Pages (from-to)	922-924
Number of pages	3
Journal	Pediatric Blood and Cancer
Volume	61
Issue number	5
DOIs	https://doi.org/10.1002/pbc.24800
State	Published - May 2014
Externally published	Yes

Keywords

Developmental therapeutics
Preclinical testing
Topoisomerase 2 inhibitor

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

Access to Document

10.1002/pbc.24800

Cite this

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title = "Initial testing (stage 1) of the topoisomerase II inhibitor pixantrone, by the pediatric preclinical testing program",

abstract = "Pixantrone, a novel aza-anthracenedione with cytotoxic activity, was tested against the PPTP in vitro panel (3.0nM to 30.0μM) and against a limited panel of PPTP Wilms tumors and sarcomas (7.5mg/kg) administered intravenously using an every 4 day×3 schedule. In vitro pixantrone showed a median relative IC50 value of 54nM (range <3nM to 1.03μM). In vivo pixantrone induced significant differences in EFS distribution compared to controls in two of eight solid tumor xenografts at dose levels relevant to human drug exposure. A complete response was observed for one Wilms tumor xenograft. Pediatr Blood Cancer 2014;61:922-924.",

keywords = "Developmental therapeutics, Preclinical testing, Topoisomerase 2 inhibitor",

author = "Kurmasheva, \{Raushan T.\} and Reynolds, \{C. Patrick\} and Kang, \{Min H.\} and Cecilia Allievi and Houghton, \{Peter J.\} and Smith, \{Malcolm A.\}",

year = "2014",

month = may,

doi = "10.1002/pbc.24800",

language = "English (US)",

volume = "61",

pages = "922--924",

journal = "Pediatric Blood and Cancer",

issn = "1545-5009",

publisher = "Wiley-Liss Inc.",

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T1 - Initial testing (stage 1) of the topoisomerase II inhibitor pixantrone, by the pediatric preclinical testing program

AU - Kurmasheva, Raushan T.

AU - Reynolds, C. Patrick

AU - Kang, Min H.

AU - Allievi, Cecilia

AU - Houghton, Peter J.

AU - Smith, Malcolm A.

PY - 2014/5

Y1 - 2014/5

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AB - Pixantrone, a novel aza-anthracenedione with cytotoxic activity, was tested against the PPTP in vitro panel (3.0nM to 30.0μM) and against a limited panel of PPTP Wilms tumors and sarcomas (7.5mg/kg) administered intravenously using an every 4 day×3 schedule. In vitro pixantrone showed a median relative IC50 value of 54nM (range <3nM to 1.03μM). In vivo pixantrone induced significant differences in EFS distribution compared to controls in two of eight solid tumor xenografts at dose levels relevant to human drug exposure. A complete response was observed for one Wilms tumor xenograft. Pediatr Blood Cancer 2014;61:922-924.

KW - Developmental therapeutics

KW - Preclinical testing

KW - Topoisomerase 2 inhibitor

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UR - https://www.scopus.com/pages/publications/84895736539#tab=citedBy

U2 - 10.1002/pbc.24800

DO - 10.1002/pbc.24800

M3 - Article

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AN - SCOPUS:84895736539

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JO - Pediatric Blood and Cancer

JF - Pediatric Blood and Cancer

IS - 5

ER -

Initial testing (stage 1) of the topoisomerase II inhibitor pixantrone, by the pediatric preclinical testing program

Abstract

Keywords

ASJC Scopus subject areas

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