Initial characterization of the carbohydrate structure of MCP-1

Yanling Jiang, Lawrence A. Tabak, Anthony J. Valente, Dana T. Graves

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

MCP-1 is the principle monocyte chemoattractant produced by tumor cells in vitro. We previously identified different isoforms of MCP-1. Here we report that two predominant isoforms of MCP-1 (13 kD and 9 kD) can be distinguished by lectin binding. The results indicate that the disaccharide galactose-β1-3D-N-acetyl galactosamine is present on the 13 kD MCP-1 isoform but not the 9 kD isoform. Glycosylation of the 13 kD MCP-1 isoform does not appear to significantly change its antigenic properties and also does not affect its capacity to induce monocyte migration.

Original languageEnglish (US)
Pages (from-to)1400-1404
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume178
Issue number3
DOIs
StatePublished - Aug 15 1991

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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