Inhibitory Effects of Interleukin 6 on Immunity: Possible Implications in Burn Patients

Daohong Zhou, Andrew M. Munster, Richard A. Winchurch

Research output: Contribution to journalArticlepeer-review

59 Scopus citations

Abstract

Certain disease states are associated with abnormal increases in the monokine interleukin 6. Increased levels of interleukin 6 have been demonstrated in serum from patients with burns and are associated with systemic increases in endotoxin levels. Using a murine in vitro experimental model, we have studied the effects of interleukin 6 on various measures of immunity. Our data indicate that levels equivalent to the concentrations found in serum of burn victims inhibit T-cell proliferation. The inhibitory effect is dose and time dependent, is specific for T cells, is not due to impairment of interleukin 2 production or of interleukin 2 receptor expression, and is dependent on macrophages. These data suggest that extraordinary increases in interleukin 6 levels may be related to impaired T-cell responses and to an increased susceptibility to infection in the patient with burns.

Original languageEnglish (US)
Pages (from-to)65-69
Number of pages5
JournalArchives of Surgery
Volume127
Issue number1
DOIs
StatePublished - Jan 1992
Externally publishedYes

ASJC Scopus subject areas

  • Surgery

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