Inhibitory effects of human gingival extracts on bone resorption in vitro

Z. Schwartz, K. Nuki, L. G. Raisz, W. A. Soskolne

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1 Scopus citations


The effects of human gingival extracts on in vitro, bone resorption were examined and related to the amount of plaque, gingival inflammation and bone resorption present at the time of sampling. Twenty patients with varying degrees of periodontal disease were used in this study. The plaque index and bleeding index were recorded. the marginal gingiva removing surgically and immediately freeze dried. Alveolar bone resorption was then measured from the cemento enamel junction (CFI) to the alveolar bone crest directly during surgical exposure or on radiographs. The bone resorting activity of extracts from freeze dried gingiva was then tested in an in vitro bone resorption assay. No bone resorting activity was noted in 17 of the 18 extracts tested and thus no correlation could be found with the clinical indices. Mean values of the T/C ratios for 18 extracts tested indicate a biphasic suppression of control resorption by the extracts. The extracts suppressed resorption stimulated by known bone resorbing agents. H [eating of the extract prior to testing eliminated this suppressive effect. It is concluded that inhibitors of bone resorption are present in human gingival extracts. Their presence may explain our inability to demonstrate bone resorhing activity in human gingiva.

Original languageEnglish (US)
Pages (from-to)455-461
Number of pages7
JournalJournal of Periodontal Research
Issue number5
StatePublished - Sep 1986

ASJC Scopus subject areas

  • Periodontics


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