Inhibition of phosphate-induced apoptosis in resting zone chondrocytes by thrombin peptide 508

Ming Zhong, Darrell H. Carney, James T. Ryaby, Zvi Schwartz, Barbara D. Boyan

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Growth plate chondrocytes are susceptible to apoptosis. Terminally differentiated chondrocytes are deleted via apoptosis, which primes the growth plate to vascular invasion and subsequent bone formation. Whether less differentiated resting zone chondrocytes are subject to the same mechanism that governs the apoptotic pathway of more differentiated growth zone chondrocytes is not known. In our current study, we demonstrated that inorganic phosphate, a key inducer of growth plate chondrocyte apoptosis, also causes apoptosis in resting zone chondrocytes, via a pathway similar to the one in growth zone chondrocytes. Our results demonstrated that the conditions that cause growth plate chondrocyte apoptosis lie in the external environment, instead of the differences in differentiation state.

Original languageEnglish (US)
Pages (from-to)56-59
Number of pages4
JournalCells Tissues Organs
Volume189
Issue number1-4
DOIs
StatePublished - Dec 1 2008

Keywords

  • Apoptosis
  • Cartilage research
  • Chondrocytes
  • Growth plate
  • Phosphate
  • Thrombin

ASJC Scopus subject areas

  • Anatomy
  • Histology

Fingerprint Dive into the research topics of 'Inhibition of phosphate-induced apoptosis in resting zone chondrocytes by thrombin peptide 508'. Together they form a unique fingerprint.

Cite this