Inhibition of p53 transactivation required for transformation by adenovirus early 1B protein

P. Renee Yew, Arnold J. Berk

Research output: Contribution to journalArticlepeer-review

467 Scopus citations

Abstract

THE cellular phosphoprotein p53 inhibits progression through the mammalian cell cycle1,2. Both p53 alleles are frequently mutated in human tumours3,4, indicating that p53 is a tumour suppressor. Recent studies have suggested that p53 functions as a transcrip-tional activator 5-8, but the significance of this activity in cell-cycle control has not been established. The adenovirus 2 (Ad2) early IB (E1B) 55K protein binds to p53 in transformed cells9 and contributes to oncogenic transformation by Ad2 (refs 10-12). Here we report that mutants of E1B 55K and wild-type Adl2 E1B 54K proteins show a strong correlation between their ability to inhibit p53-mediated transcriptional activation and their ability to cooperate with adenovirus El A protein in the transformation of primary cells. These results indicate that p53 probably inhibits cell cycling by functioning as a transcription factor.

Original languageEnglish (US)
Pages (from-to)82-85
Number of pages4
JournalNature
Volume357
Issue number6373
DOIs
StatePublished - Jan 1 1992
Externally publishedYes

ASJC Scopus subject areas

  • General

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