Inhibition of Mycoplasma pneumoniae hemadsorption and adherence to respiratory epithelium by antibodies to a membrane protein

D. C. Krause, J. B. Baseman

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Antiserum and purified immunoglobulin directed against Mycoplasma pneumoniae membrane protein P1 were examined for their influence on mycoplasma viability, metabolism, and cytadsorption. Anti-P1 immunoglobulin inhibited adherence of M. pneumoniae to hamster tracheal rings in vitro by up to 80% and inhibited hemadsorption by greater than 90%. Cytadsorption was also inhibited by anti-P1 Fab fragments. Anti-P1 antibodies had no effect on M. pneumoniae viability or metabolism. The data indicate that anti-P1 antibody obstructs the interaction of M. pneumoniae adhesin P1 with its host receptors.

Original languageEnglish (US)
Pages (from-to)1180-1186
Number of pages7
JournalInfection and Immunity
Volume39
Issue number3
StatePublished - 1983

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Hemadsorption
Respiratory Mucosa
Mycoplasma pneumoniae
Membrane Proteins
Antibodies
Immunoglobulins
Anti-Idiotypic Antibodies
Immunoglobulin Fab Fragments
Mycoplasma
Cricetinae
Immune Sera

ASJC Scopus subject areas

  • Immunology

Cite this

Inhibition of Mycoplasma pneumoniae hemadsorption and adherence to respiratory epithelium by antibodies to a membrane protein. / Krause, D. C.; Baseman, J. B.

In: Infection and Immunity, Vol. 39, No. 3, 1983, p. 1180-1186.

Research output: Contribution to journalArticle

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