Abstract
Antiserum and purified immunoglobulin directed against Mycoplasma pneumoniae membrane protein P1 were examined for their influence on mycoplasma viability, metabolism, and cytadsorption. Anti-P1 immunoglobulin inhibited adherence of M. pneumoniae to hamster tracheal rings in vitro by up to 80% and inhibited hemadsorption by greater than 90%. Cytadsorption was also inhibited by anti-P1 Fab fragments. Anti-P1 antibodies had no effect on M. pneumoniae viability or metabolism. The data indicate that anti-P1 antibody obstructs the interaction of M. pneumoniae adhesin P1 with its host receptors.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1180-1186 |
| Number of pages | 7 |
| Journal | Infection and Immunity |
| Volume | 39 |
| Issue number | 3 |
| State | Published - Jan 1 1983 |
ASJC Scopus subject areas
- Parasitology
- Microbiology
- Immunology
- Infectious Diseases
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Krause, D. C., & Baseman, J. B. (1983). Inhibition of Mycoplasma pneumoniae hemadsorption and adherence to respiratory epithelium by antibodies to a membrane protein. Infection and Immunity, 39(3), 1180-1186.