Inhibition of mouse skin tumor promotion by several inhibitors of arachidonic acid metabolism

Susan M. Fischer, Gerald D. Mills, Thomas J Slaga

Research output: Contribution to journalArticle

151 Citations (Scopus)

Abstract

12-O-Tetradecanoylphorbol-13-acetate promotion of skin tumors in mice can be inhibited by topical application of either the phospholipase A2 inhibitor dibromoacetophenone or the cyclooxygenase-lipoxygenase inhibitors 5,8,11,14-eicosatetrayonic acid or 1-phenyl-3-pyrazolidinone. The phospholipase A2 inhibitors in particular appear to be among the most potent inhibitors of skin tumor promotion known. These results support the hypothesis that at least some of the products of arachidonic acid transformation are essential for tumor promotion.

Original languageEnglish (US)
Pages (from-to)1243-1245
Number of pages3
JournalCarcinogenesis
Volume3
Issue number11
DOIs
StatePublished - 1982
Externally publishedYes

Fingerprint

Arachidonic Acid
Metabolism
Skin
Inhibitor
Mouse
Tumors
Tumor
Acids
Phospholipase A2 Inhibitors
Lipoxygenase Inhibitors
Neoplasms
Cyclooxygenase Inhibitors
Tetradecanoylphorbol Acetate
Promotion

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Physiology
  • Behavioral Neuroscience
  • Cancer Research

Cite this

Inhibition of mouse skin tumor promotion by several inhibitors of arachidonic acid metabolism. / Fischer, Susan M.; Mills, Gerald D.; Slaga, Thomas J.

In: Carcinogenesis, Vol. 3, No. 11, 1982, p. 1243-1245.

Research output: Contribution to journalArticle

Fischer, Susan M. ; Mills, Gerald D. ; Slaga, Thomas J. / Inhibition of mouse skin tumor promotion by several inhibitors of arachidonic acid metabolism. In: Carcinogenesis. 1982 ; Vol. 3, No. 11. pp. 1243-1245.
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