Inhibition of mitochondrial oxidative phosphorylation by 2-methyl-4-dimethylaminoazobenzene

P. Sai Kumar; C. K.Ramakrishna Kurup

doi:10.1016/0005-2728(84)90240-8

Inhibition of mitochondrial oxidative phosphorylation by 2-methyl-4-dimethylaminoazobenzene

P. Sai Kumar, C. K.Ramakrishna Kurup

Pathology

Research output: Contribution to journal › Article

6 Scopus citations

Abstract

The azodye 2-methyl-4-dimethylaminoazobenzene inhibited oxidation and phosphorylation in tightly coupled rat liver mitochondria. Phosphorylation was more sensitive to the inhibitory action of the azodye than was the oxidation of succinate or ascorbate. The oxidation of NAD⁺-linked substrate was severely inhibited by the compound. In submitochondrial particles, only NADH oxidation was sensitive. The site of inhibition has been identified to lie between the dehydrogenase flavoprotein and ubiquinone.

Original language	English (US)
Pages (from-to)	263-266
Number of pages	4
Journal	BBA - Bioenergetics
Volume	766
Issue number	1
DOIs	https://doi.org/10.1016/0005-2728(84)90240-8
Publication status	Published - Jul 27 1984

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Keywords

(Rat liver mitochondria)
2-Methyl-4-dimethylaminoazobenzene
Azodye
Electron transport inhibitor
Oxidative phosphorylation
Respiratory chain

ASJC Scopus subject areas

Biophysics
Biochemistry
Cell Biology

Cite this

Kumar, P. S., & Kurup, C. K. R. (1984). Inhibition of mitochondrial oxidative phosphorylation by 2-methyl-4-dimethylaminoazobenzene. BBA - Bioenergetics, 766(1), 263-266. https://doi.org/10.1016/0005-2728(84)90240-8

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10.1016/0005-2728(84)90240-8