Inhibition of mitochondrial oxidative phosphorylation by 2-methyl-4-dimethylaminoazobenzene

P. Sai Kumar, C. K.Ramakrishna Kurup

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

The azodye 2-methyl-4-dimethylaminoazobenzene inhibited oxidation and phosphorylation in tightly coupled rat liver mitochondria. Phosphorylation was more sensitive to the inhibitory action of the azodye than was the oxidation of succinate or ascorbate. The oxidation of NAD+-linked substrate was severely inhibited by the compound. In submitochondrial particles, only NADH oxidation was sensitive. The site of inhibition has been identified to lie between the dehydrogenase flavoprotein and ubiquinone.

Original languageEnglish (US)
Pages (from-to)263-266
Number of pages4
JournalBBA - Bioenergetics
Volume766
Issue number1
DOIs
StatePublished - Jul 27 1984
Externally publishedYes

Keywords

  • (Rat liver mitochondria)
  • 2-Methyl-4-dimethylaminoazobenzene
  • Azodye
  • Electron transport inhibitor
  • Oxidative phosphorylation
  • Respiratory chain

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Cell Biology

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