Inhibition of luteinizing hormone release and ovulation in PMS-treated rats by peripherally administered melatonin

R. J. Reiter, S. Sorrentino

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

The influence of intraperitoneally administered melatonin on ovulation and the plasma content of luteinizing hormone in pregnant mare's serum (PMS) treated immature rats was tested. Melatonin, administered in three equivalent doses of 500 μg each at 2:00, 3:00 and 4:00 P. M. on the second day after PMS administration, reduced the number of rats that ovulated. Melatonin also prevented the rise in plasma luteinizing hormone which occurred in the majority of the control animals at 57 hours after PMS administration.

Original languageEnglish (US)
Pages (from-to)385-392
Number of pages8
JournalContraception
Volume4
Issue number6
DOIs
StatePublished - Dec 1971
Externally publishedYes

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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