TY - JOUR
T1 - Inhibition of interferon production and antiviral action in mouse cells by 4,5′,8-trimethylpsoralen activated with near ultraviolet light
AU - Sakaguchi, A. Y.
AU - Stevenson, D.
AU - Gordon, I.
PY - 1980/3
Y1 - 1980/3
N2 - The DNA of mammalian cells treated with 4,5′,8-trimethylpsoralen (Trioxsalen) is crosslinked (preventing transcription) only after photoactivation with near ultraviolet light. Suppression of gene action in cocultivated or fused cultures, including both induction and antiviral action of fibroblast interferon, can consequently be limited to pretreated cells, an advantage over actinomycin treatment.
AB - The DNA of mammalian cells treated with 4,5′,8-trimethylpsoralen (Trioxsalen) is crosslinked (preventing transcription) only after photoactivation with near ultraviolet light. Suppression of gene action in cocultivated or fused cultures, including both induction and antiviral action of fibroblast interferon, can consequently be limited to pretreated cells, an advantage over actinomycin treatment.
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U2 - 10.1007/BF01320762
DO - 10.1007/BF01320762
M3 - Article
C2 - 6154450
AN - SCOPUS:0018874336
SN - 0304-8608
VL - 63
SP - 69
EP - 74
JO - Archives of Virology
JF - Archives of Virology
IS - 1
ER -