Inhibition of interferon production and antiviral action in mouse cells by 4,5′,8-trimethylpsoralen activated with near ultraviolet light

A. Y. Sakaguchi; D. Stevenson; I. Gordon

doi:10.1007/BF01320762

Inhibition of interferon production and antiviral action in mouse cells by 4,5′,8-trimethylpsoralen activated with near ultraviolet light

A. Y. Sakaguchi, D. Stevenson, I. Gordon

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2 Scopus citations

Abstract

The DNA of mammalian cells treated with 4,5′,8-trimethylpsoralen (Trioxsalen) is crosslinked (preventing transcription) only after photoactivation with near ultraviolet light. Suppression of gene action in cocultivated or fused cultures, including both induction and antiviral action of fibroblast interferon, can consequently be limited to pretreated cells, an advantage over actinomycin treatment.

Original language	English (US)
Pages (from-to)	69-74
Number of pages	6
Journal	Archives of Virology
Volume	63
Issue number	1
DOIs	https://doi.org/10.1007/BF01320762
State	Published - Mar 1980
Externally published	Yes

ASJC Scopus subject areas

Virology

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10.1007/BF01320762

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title = "Inhibition of interferon production and antiviral action in mouse cells by 4,5′,8-trimethylpsoralen activated with near ultraviolet light",

abstract = "The DNA of mammalian cells treated with 4,5′,8-trimethylpsoralen (Trioxsalen) is crosslinked (preventing transcription) only after photoactivation with near ultraviolet light. Suppression of gene action in cocultivated or fused cultures, including both induction and antiviral action of fibroblast interferon, can consequently be limited to pretreated cells, an advantage over actinomycin treatment.",

author = "Sakaguchi, {A. Y.} and D. Stevenson and I. Gordon",

year = "1980",

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AU - Sakaguchi, A. Y.

AU - Stevenson, D.

AU - Gordon, I.

PY - 1980/3

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N2 - The DNA of mammalian cells treated with 4,5′,8-trimethylpsoralen (Trioxsalen) is crosslinked (preventing transcription) only after photoactivation with near ultraviolet light. Suppression of gene action in cocultivated or fused cultures, including both induction and antiviral action of fibroblast interferon, can consequently be limited to pretreated cells, an advantage over actinomycin treatment.

AB - The DNA of mammalian cells treated with 4,5′,8-trimethylpsoralen (Trioxsalen) is crosslinked (preventing transcription) only after photoactivation with near ultraviolet light. Suppression of gene action in cocultivated or fused cultures, including both induction and antiviral action of fibroblast interferon, can consequently be limited to pretreated cells, an advantage over actinomycin treatment.

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Inhibition of interferon production and antiviral action in mouse cells by 4,5′,8-trimethylpsoralen activated with near ultraviolet light

Abstract

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