Inhibition of interferon production and antiviral action in mouse cells by 4,5′,8-trimethylpsoralen activated with near ultraviolet light

A. Y. Sakaguchi, D. Stevenson, I. Gordon

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The DNA of mammalian cells treated with 4,5′,8-trimethylpsoralen (Trioxsalen) is crosslinked (preventing transcription) only after photoactivation with near ultraviolet light. Suppression of gene action in cocultivated or fused cultures, including both induction and antiviral action of fibroblast interferon, can consequently be limited to pretreated cells, an advantage over actinomycin treatment.

Original languageEnglish (US)
Pages (from-to)69-74
Number of pages6
JournalArchives of Virology
Volume63
Issue number1
DOIs
StatePublished - Mar 1 1980
Externally publishedYes

ASJC Scopus subject areas

  • Virology

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