Inhibition of Induced L–Ornithine Decarboxylase Stimulation and Erythrodifferentiation in Friend Erythroleukemia Cells by 2',5'–Isoadenylate Trimer Core

Yair Gazitt

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Friend erythroleukemia cells were induced to differentiate by hexamethylene bisacetamide, dimethyl sulfoxide, and dimethylformamide. The effect of 2',5'–oligoadenosine (trimer core) on cell growth, on erythrodifferentiation, and on the level of L–ornithine decarboxylase was tested. The results indicated a dose response-inhibitory effect of the trimer core on erythrodifferentiation. The optimal dose of the trimer inhibited hexamethylene bisacetamide and dimethyl sulfoxide stimulation of L–ornithine decarboxylase activity, with no apparent effect on cell growth, resembling the effect of high doses of interferon on both erythrodifferentiation and L–ornithine decarboxylase reported previously. Research.

Original languageEnglish (US)
Pages (from-to)2959-2961
Number of pages3
JournalCancer Research
Volume41
Issue number7
StatePublished - Jul 1 1981
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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