Inhibition of human chorionic gonadotrophin induced hypertrophy of the ovaries and uterus in immature mice by some pineal indoles, 6 hydroxymelatonin and arginine vasotocin

M. K. Vaughan, G. M. Vaughan, Russel J Reiter

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Administration of the indoles 5 methoxytryptophol, 6 hydroxymelatonin, melatonin N acetylserotonin or 5 methoxyindole 3 acetic acid (six 100 μg injections given at intervals of 12 h) inhibited both the absolute and relative ovarian and uterine weights of immature female mice pre treated with HCG. Administration of 5 hydroxytryptophol or 5 methoxytryptamine at the same dosage inhibited ovarian but not uterine hypertrophy in mice pre treated with HCG.

Original languageEnglish (US)
Pages (from-to)397-400
Number of pages4
JournalJournal of Endocrinology
Volume68
Issue number3
StatePublished - 1976

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Vasotocin
Indoles
Chorionic Gonadotropin
Hypertrophy
Uterus
Hydroxytryptophol
Ovary
5-Methoxytryptamine
Melatonin
Weights and Measures
Injections
6-hydroxymelatonin
5-methoxyindoleacetic acid
methoxytryptophol
N-acetylserotonin

ASJC Scopus subject areas

  • Endocrinology

Cite this

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abstract = "Administration of the indoles 5 methoxytryptophol, 6 hydroxymelatonin, melatonin N acetylserotonin or 5 methoxyindole 3 acetic acid (six 100 μg injections given at intervals of 12 h) inhibited both the absolute and relative ovarian and uterine weights of immature female mice pre treated with HCG. Administration of 5 hydroxytryptophol or 5 methoxytryptamine at the same dosage inhibited ovarian but not uterine hypertrophy in mice pre treated with HCG.",
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