Inhibition of HOS expression and activities by Wnt pathway

Vladimir S. Spiegelman, Weigang Tang, Masaru Katoh, Thomas J Slaga, Serge Y. Fuchs

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

βTrCP and HOS are closely related F-box proteins, which play key roles in ubiquitination and degradation of β-catenin and IκB through associating with those phosphorylated substrates and recruiting SCF E3 ubiquitin ligase. Here we report that activation of Wnt/β-catenin signal transduction pathway elevates βTrCP levels but inhibits expression of HOS in 293T cells. Similar disparity is likely to exist in human colorectal tumors. In the NIH3T3 cells, which express HOS, but not βTrCP, Wnt/β-catenin signaling leads to inhibition of HOS promoter activity and NF-κB-driven transcription as well as to stabilization of β-catenin. These results indicate that expression and activities of HOS are negatively regulated by Wnt/β-catenin pathway.

Original languageEnglish (US)
Pages (from-to)856-860
Number of pages5
JournalOncogene
Volume21
Issue number5
DOIs
StatePublished - Jan 24 2002
Externally publishedYes

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Keywords

  • F-box protein
  • HOS
  • NF-κB
  • Ubiquitin ligase
  • β-catenin
  • βTrCP

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

Cite this

Spiegelman, V. S., Tang, W., Katoh, M., Slaga, T. J., & Fuchs, S. Y. (2002). Inhibition of HOS expression and activities by Wnt pathway. Oncogene, 21(5), 856-860. https://doi.org/10.1038/sj.onc.1205132