Inhibition of Estrogen Receptor Action by a Naturally Occurring Variant in Human Breast Tumors

Suzanne A.W. Fuqua, Saundra D. Fitzgerald, D. Craig Allred, Richard M. Elledge, William L. McGuire

Research output: Contribution to journalArticlepeer-review

254 Scopus citations

Abstract

It is fairly well accepted that the presence of estrogen receptor (ER) and progesterone receptor (PgR) identifies breast cancer patients with a lower risk of relapse and better overall survival. But patients with discordant receptors, the ER^/PgR” phenotype, are often intermediate in clinical response. We focused upon this group of patients and have identified a truncated ER which is abundant in some ER+/PgR~ breast tumors and which inhibits the binding of wild-type ER to its cognate response element. This variant interferes in a dominant negative manner with wild-type ER function and may represent a mechanism for modulation of estrogen responsiveness.

Original languageEnglish (US)
Pages (from-to)483-486
Number of pages4
JournalCancer Research
Volume52
Issue number2
StatePublished - Jan 1992

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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