TY - JOUR
T1 - Inhibition of entry of HIV-1 in neural cell lines by antibodies against galactosyl ceramide
AU - Harouse, Janet M.
AU - Bhat, Shama
AU - Spitalnik, Steven L.
AU - Laughlin, Mark
AU - Stefano, Kelly
AU - Silberberg, Donald H.
AU - Gonzalez-Scarano, Francisco
PY - 1991
Y1 - 1991
N2 - Although the CD4 molecule is the principal cellular receptor for the human immunodeficiency virus (HIV), several CD4-negative cell lines are susceptible to infection with one or more HIV strains. These findings indicate that there are alternate modes of viral entry, perhaps involving one or more receptor molecules. Antibodies against galactosyl ceramide (galactocerebroside, or GalC) inhibited viral internalization and infection in two CD4-negative cell lines derived from the nervous system: U373-MG and SK-N-MC. Furthermore, recombinant HIV surface glycoprotein gp120 bound to GalC but not to other glycolipids. These results suggest a role for GalC or a highly related molecule in HIV entry into neutral cells.
AB - Although the CD4 molecule is the principal cellular receptor for the human immunodeficiency virus (HIV), several CD4-negative cell lines are susceptible to infection with one or more HIV strains. These findings indicate that there are alternate modes of viral entry, perhaps involving one or more receptor molecules. Antibodies against galactosyl ceramide (galactocerebroside, or GalC) inhibited viral internalization and infection in two CD4-negative cell lines derived from the nervous system: U373-MG and SK-N-MC. Furthermore, recombinant HIV surface glycoprotein gp120 bound to GalC but not to other glycolipids. These results suggest a role for GalC or a highly related molecule in HIV entry into neutral cells.
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U2 - 10.1126/science.1857969
DO - 10.1126/science.1857969
M3 - Article
C2 - 1857969
AN - SCOPUS:0026324207
VL - 253
SP - 320
EP - 323
JO - Science
JF - Science
SN - 0036-8075
IS - 5017
ER -