Inhibition of entry of HIV-1 in neural cell lines by antibodies against galactosyl ceramide

Janet M. Harouse, Shama Bhat, Steven L. Spitalnik, Mark Laughlin, Kelly Stefano, Donald H. Silberberg, Francisco Gonzalez-Scarano

Research output: Contribution to journalArticlepeer-review

447 Scopus citations

Abstract

Although the CD4 molecule is the principal cellular receptor for the human immunodeficiency virus (HIV), several CD4-negative cell lines are susceptible to infection with one or more HIV strains. These findings indicate that there are alternate modes of viral entry, perhaps involving one or more receptor molecules. Antibodies against galactosyl ceramide (galactocerebroside, or GalC) inhibited viral internalization and infection in two CD4-negative cell lines derived from the nervous system: U373-MG and SK-N-MC. Furthermore, recombinant HIV surface glycoprotein gp120 bound to GalC but not to other glycolipids. These results suggest a role for GalC or a highly related molecule in HIV entry into neutral cells.

Original languageEnglish (US)
Pages (from-to)320-323
Number of pages4
JournalScience
Volume253
Issue number5017
DOIs
StatePublished - 1991

ASJC Scopus subject areas

  • General

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