Inhibition of Dunning tumor growth by melatonin

R. Philo, A. S. Berkowitz

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Injections of the pineal hormone melatonin reduced growth and increased doubling time of the R3327H Dunning prostatic adenocarcinoma in the Copenhagen X Fisher rat. This occurred even though testosterone levels (50% of normal) were ostensibly high enough to maintain normal tumor growth. Melatonin may act directly upon the conversion of testosterone to dihydrotestosterone to inhibit tumor growth. Alternatively, a more complicated mechanism may be involved since studies on MCF breast cancer tissue indicate an estrogen requirement for inhibition of growth by melatonin.

Original languageEnglish (US)
Pages (from-to)1099-1102
Number of pages4
JournalJournal of Urology
Issue number5
StatePublished - Jan 1 1988
Externally publishedYes

ASJC Scopus subject areas

  • Urology


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