Abstract
Injections of the pineal hormone melatonin reduced growth and increased doubling time of the R3327H Dunning prostatic adenocarcinoma in the Copenhagen X Fisher rat. This occurred even though testosterone levels (50% of normal) were ostensibly high enough to maintain normal tumor growth. Melatonin may act directly upon the conversion of testosterone to dihydrotestosterone to inhibit tumor growth. Alternatively, a more complicated mechanism may be involved since studies on MCF breast cancer tissue indicate an estrogen requirement for inhibition of growth by melatonin.
Original language | English (US) |
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Pages (from-to) | 1099-1102 |
Number of pages | 4 |
Journal | Journal of Urology |
Volume | 139 |
Issue number | 5 |
DOIs | |
State | Published - Jan 1 1988 |
Externally published | Yes |
ASJC Scopus subject areas
- Urology