Inhibition of cell-free protein synthesis by analogues of aurintricarboxylic acid.

B. L. Kreamer, J. Anderson, D. S. Liu, M. B. Sparks, A. Richardson

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8 Scopus citations

Abstract

Aurintricarboxylic acid is a potent inhibitor of cell-free protein synthesis by the post-mitochondrial supernatant of chick brain and the translation of mRNA by wheat germ lysate. Comparison of commercially available and chemically synthesized analogues of aurintricarboxylic acid indicates that the unique aurin triphenyl methane ring system and the carboxylic acid groups are both necessary for inhibition of cell-free protein synthesis in both systems.

Original languageEnglish (US)
Pages (from-to)1162-1167
Number of pages6
JournalCanadian journal of biochemistry
Volume56
Issue number12
DOIs
StatePublished - Dec 1978

ASJC Scopus subject areas

  • Medicine(all)

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    Kreamer, B. L., Anderson, J., Liu, D. S., Sparks, M. B., & Richardson, A. (1978). Inhibition of cell-free protein synthesis by analogues of aurintricarboxylic acid. Canadian journal of biochemistry, 56(12), 1162-1167. https://doi.org/10.1139/o78-182