Inhibition of cell-free protein synthesis by analogues of aurintricarboxylic acid.

B. L. Kreamer; J. Anderson; D. S. Liu; M. B. Sparks; A. Richardson

doi:10.1139/o78-182

Inhibition of cell-free protein synthesis by analogues of aurintricarboxylic acid.

B. L. Kreamer, J. Anderson, D. S. Liu, M. B. Sparks, A. Richardson

Barshop Institute

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Aurintricarboxylic acid is a potent inhibitor of cell-free protein synthesis by the post-mitochondrial supernatant of chick brain and the translation of mRNA by wheat germ lysate. Comparison of commercially available and chemically synthesized analogues of aurintricarboxylic acid indicates that the unique aurin triphenyl methane ring system and the carboxylic acid groups are both necessary for inhibition of cell-free protein synthesis in both systems.

Original language	English (US)
Pages (from-to)	1162-1167
Number of pages	6
Journal	Canadian journal of biochemistry
Volume	56
Issue number	12
DOIs	https://doi.org/10.1139/o78-182
State	Published - Dec 1978

ASJC Scopus subject areas

Medicine(all)

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title = "Inhibition of cell-free protein synthesis by analogues of aurintricarboxylic acid.",

abstract = "Aurintricarboxylic acid is a potent inhibitor of cell-free protein synthesis by the post-mitochondrial supernatant of chick brain and the translation of mRNA by wheat germ lysate. Comparison of commercially available and chemically synthesized analogues of aurintricarboxylic acid indicates that the unique aurin triphenyl methane ring system and the carboxylic acid groups are both necessary for inhibition of cell-free protein synthesis in both systems.",

author = "Kreamer, {B. L.} and J. Anderson and Liu, {D. S.} and Sparks, {M. B.} and A. Richardson",

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