Inhibition of CD44 N- and O-linked glycosylation decreases endometrial cell lines attachment to peritoneal mesothelial cells

Allison K. Rodgers, Anitha Nair, Peter A. Binkley, Rajeshwar Tekmal, Robert S. Schenken

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

The attachment of endometrial epithelial cells (EECs) and endometrial stromal cells (ESCs) to peritoneal mesothelial cells (PMCs) with and without inhibition of N- and O-linked glycosylation, the viability of EECs and ESCs, and the expression of CD44 surface density were evaluated. Inhibition of CD44 N- and O-linked glycosylation by using tunicamycin and/or B-GalNAc statistically significantly inhibited endometrial cell attachment to peritoneal mesothelial cells, suggesting a role in establishment of early endometriotic lesions.

Original languageEnglish (US)
Pages (from-to)823-825
Number of pages3
JournalFertility and sterility
Volume95
Issue number2
DOIs
StatePublished - Feb 2011

Keywords

  • CD44
  • endometriosis
  • glycosylation

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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