Abstract
The anti-tumor activity of the sea snake venom (Hydrophis spiralis) was evaluated against Ehrlich's Ascites Carcinoma (EAC) in Swiss albino mice and HeLa and Hep2 tumor cell cultures. Among the different dose tested 4.18 μg mL-1 at 24 h was found to effectively inhibit cancer cell proliferation. The same dose on EAC-bearing mice by i.p. injection significantly reduced the tumor growth and was demonstrated by increased life span of the mice by 182.81%.
Original language | English (US) |
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Pages (from-to) | 186-190 |
Number of pages | 5 |
Journal | International Journal of Cancer Research |
Volume | 3 |
Issue number | 4 |
DOIs | |
State | Published - 2007 |
Externally published | Yes |
Keywords
- Antitumor
- Cell line
- Ehrlich's ascites carcinoma
- Hydrophis spiralis
- Sea snake venom
ASJC Scopus subject areas
- Oncology
- Cancer Research