Inhibition by restricted-calorie diet of lymphoproliferative disease and renal damage in MRL/lpr mice

G. Fernandes, R. A. Good

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

Restriction of calorie intake from the time of weaning greatly prolongs life, and it inhibits development and expression of the lymphoproliferative syndrome, renal disease, and decline of certain immunologic functions with age in MRL/lpr mice. This dramatic influence of diet on mice of this short-lived autoimmunity-prone strain, while associated with decreased rate of growth, is not associated with debilitation or apparent disease in the MRL/lpr mice. The massive lymphadenopathy and splenomegaly that developed in the putatively well-fed animals was prevented by dietary restriction, as were histopathologic abnormalities of thymus, spleen, lymph nodes, and kidneys.

Original languageEnglish (US)
Pages (from-to)6144-6148
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume81
Issue number19 I
DOIs
StatePublished - 1984

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Inhibition by restricted-calorie diet of lymphoproliferative disease and renal damage in MRL/lpr mice'. Together they form a unique fingerprint.

Cite this