TY - JOUR
T1 - Inhibition by restricted-calorie diet of lymphoproliferative disease and renal damage in MRL/lpr mice
AU - Fernandes, G.
AU - Good, R. A.
PY - 1984
Y1 - 1984
N2 - Restriction of calorie intake from the time of weaning greatly prolongs life, and it inhibits development and expression of the lymphoproliferative syndrome, renal disease, and decline of certain immunologic functions with age in MRL/lpr mice. This dramatic influence of diet on mice of this short-lived autoimmunity-prone strain, while associated with decreased rate of growth, is not associated with debilitation or apparent disease in the MRL/lpr mice. The massive lymphadenopathy and splenomegaly that developed in the putatively well-fed animals was prevented by dietary restriction, as were histopathologic abnormalities of thymus, spleen, lymph nodes, and kidneys.
AB - Restriction of calorie intake from the time of weaning greatly prolongs life, and it inhibits development and expression of the lymphoproliferative syndrome, renal disease, and decline of certain immunologic functions with age in MRL/lpr mice. This dramatic influence of diet on mice of this short-lived autoimmunity-prone strain, while associated with decreased rate of growth, is not associated with debilitation or apparent disease in the MRL/lpr mice. The massive lymphadenopathy and splenomegaly that developed in the putatively well-fed animals was prevented by dietary restriction, as were histopathologic abnormalities of thymus, spleen, lymph nodes, and kidneys.
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U2 - 10.1073/pnas.81.19.6144
DO - 10.1073/pnas.81.19.6144
M3 - Article
C2 - 6592606
AN - SCOPUS:0007004669
VL - 81
SP - 6144
EP - 6148
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
SN - 0027-8424
IS - 19 I
ER -