Inherited metabolic disorders and cerebral infarction

Kavita Kalidas, Reza Behrouz

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

The association of genetic factors and cerebral infarction (CI) has long been established. A positive family history alone is a recognized risk factor for CI and vascular events in general. However, there are certain inherited conditions that further increase the risk of stroke. These conditions are generally metabolic and mitochondrial genetic defects that have variable modes of inheritance. This article reviews major inherited metabolic disorders that predispose an individual to CI. Ten main conditions will be discussed: Fabry's disease, cerebrotendinous xanthomatosis, tangier disease, familial hypercholesterolemia, homocystinuria, methylmalonic acidemia, glutaric aciduria type I, propionic acidemia, ornithine transcarbamylase deficiency and mitochondrial encephalopathy, lactic acidosis and stroke-like phenomenon.

Original languageEnglish (US)
Pages (from-to)1731-1741
Number of pages11
JournalExpert Review of Neurotherapeutics
Volume8
Issue number11
DOIs
StatePublished - Nov 1 2008
Externally publishedYes

Fingerprint

Cerebral Infarction
Tangier Disease
Cerebrotendinous Xanthomatosis
Propionic Acidemia
Ornithine Carbamoyltransferase Deficiency Disease
Stroke
Homocystinuria
Fabry Disease
Lactic Acidosis
Hyperlipoproteinemia Type II
Blood Vessels

Keywords

  • Cerebral infarction
  • Cerebrotendinous xanthomatosis
  • Fabry's disease
  • Familial hypercholesterolemia
  • Glutaric acidemia
  • Homocystinuria
  • MELAS
  • Metabolic disease
  • Methylmalonic acidemia
  • Ornithine transcarbamylase deficiency
  • Propionic academia
  • Stroke

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Pharmacology (medical)

Cite this

Inherited metabolic disorders and cerebral infarction. / Kalidas, Kavita; Behrouz, Reza.

In: Expert Review of Neurotherapeutics, Vol. 8, No. 11, 01.11.2008, p. 1731-1741.

Research output: Contribution to journalReview article

Kalidas, Kavita ; Behrouz, Reza. / Inherited metabolic disorders and cerebral infarction. In: Expert Review of Neurotherapeutics. 2008 ; Vol. 8, No. 11. pp. 1731-1741.
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