Inhaled voriconazole for prevention of invasive pulmonary aspergillosis

Justin A. Tolman; Nathan P. Wiederhold; Jason T. McConville; Laura K. Najvar; Rosie Bocanegra; Jay I. Peters; Jacqueline J. Coalson; John R. Graybill; Thomas F. Patterson; Robert O. Williams

doi:10.1128/AAC.01657-08

Inhaled voriconazole for prevention of invasive pulmonary aspergillosis

Justin A. Tolman
, Nathan P. Wiederhold
, Jason T. McConville
, Laura K. Najvar
, Rosie Bocanegra
, Jay I. Peters
, Jacqueline J. Coalson
, John R. Graybill
, Thomas F. Patterson
, Robert O. Williams

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

Targeted airway delivery of antifungals as prophylaxis against invasive aspergillosis may lead to high lung drug concentrations while avoiding toxicities associated with systemically administered agents. We evaluated the effectiveness of aerosolizing the intravenous formulation of voriconazole as prophylaxis against invasive pulmonary aspergillosis caused by Aspergillus fumigatus in an established murine model. Inhaled voriconazole significantly improved survival and limited the extent of invasive disease, as assessed by histopathology, compared to control and amphotericin B treatments.

Original language	English (US)
Pages (from-to)	2613-2615
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	53
Issue number	6
DOIs	https://doi.org/10.1128/AAC.01657-08
State	Published - Jun 2009

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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10.1128/AAC.01657-08

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title = "Inhaled voriconazole for prevention of invasive pulmonary aspergillosis",

abstract = "Targeted airway delivery of antifungals as prophylaxis against invasive aspergillosis may lead to high lung drug concentrations while avoiding toxicities associated with systemically administered agents. We evaluated the effectiveness of aerosolizing the intravenous formulation of voriconazole as prophylaxis against invasive pulmonary aspergillosis caused by Aspergillus fumigatus in an established murine model. Inhaled voriconazole significantly improved survival and limited the extent of invasive disease, as assessed by histopathology, compared to control and amphotericin B treatments.",

author = "Tolman, \{Justin A.\} and Wiederhold, \{Nathan P.\} and McConville, \{Jason T.\} and Najvar, \{Laura K.\} and Rosie Bocanegra and Peters, \{Jay I.\} and Coalson, \{Jacqueline J.\} and Graybill, \{John R.\} and Patterson, \{Thomas F.\} and Williams, \{Robert O.\}",

year = "2009",

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language = "English (US)",

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AU - Tolman, Justin A.

AU - Wiederhold, Nathan P.

AU - McConville, Jason T.

AU - Najvar, Laura K.

AU - Bocanegra, Rosie

AU - Peters, Jay I.

AU - Coalson, Jacqueline J.

AU - Graybill, John R.

AU - Patterson, Thomas F.

AU - Williams, Robert O.

PY - 2009/6

Y1 - 2009/6

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AB - Targeted airway delivery of antifungals as prophylaxis against invasive aspergillosis may lead to high lung drug concentrations while avoiding toxicities associated with systemically administered agents. We evaluated the effectiveness of aerosolizing the intravenous formulation of voriconazole as prophylaxis against invasive pulmonary aspergillosis caused by Aspergillus fumigatus in an established murine model. Inhaled voriconazole significantly improved survival and limited the extent of invasive disease, as assessed by histopathology, compared to control and amphotericin B treatments.

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JO - Antimicrobial agents and chemotherapy

JF - Antimicrobial agents and chemotherapy

IS - 6

ER -

Inhaled voriconazole for prevention of invasive pulmonary aspergillosis

Abstract

ASJC Scopus subject areas

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