TY - JOUR
T1 - Inhaled voriconazole for prevention of invasive pulmonary aspergillosis
AU - Tolman, Justin A.
AU - Wiederhold, Nathan P.
AU - McConville, Jason T.
AU - Najvar, Laura K.
AU - Bocanegra, Rosie
AU - Peters, Jay I.
AU - Coalson, Jacqueline J.
AU - Graybill, John R.
AU - Patterson, Thomas F.
AU - Williams, Robert O.
PY - 2009/6
Y1 - 2009/6
N2 - Targeted airway delivery of antifungals as prophylaxis against invasive aspergillosis may lead to high lung drug concentrations while avoiding toxicities associated with systemically administered agents. We evaluated the effectiveness of aerosolizing the intravenous formulation of voriconazole as prophylaxis against invasive pulmonary aspergillosis caused by Aspergillus fumigatus in an established murine model. Inhaled voriconazole significantly improved survival and limited the extent of invasive disease, as assessed by histopathology, compared to control and amphotericin B treatments.
AB - Targeted airway delivery of antifungals as prophylaxis against invasive aspergillosis may lead to high lung drug concentrations while avoiding toxicities associated with systemically administered agents. We evaluated the effectiveness of aerosolizing the intravenous formulation of voriconazole as prophylaxis against invasive pulmonary aspergillosis caused by Aspergillus fumigatus in an established murine model. Inhaled voriconazole significantly improved survival and limited the extent of invasive disease, as assessed by histopathology, compared to control and amphotericin B treatments.
UR - http://www.scopus.com/inward/record.url?scp=67049107823&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67049107823&partnerID=8YFLogxK
U2 - 10.1128/AAC.01657-08
DO - 10.1128/AAC.01657-08
M3 - Article
C2 - 19289523
AN - SCOPUS:67049107823
SN - 0066-4804
VL - 53
SP - 2613
EP - 2615
JO - Antimicrobial agents and chemotherapy
JF - Antimicrobial agents and chemotherapy
IS - 6
ER -