Influenza-Induced Oxidative Stress Sensitizes Lung Cells to Bacterial-Toxin-Mediated Necroptosis

Norberto Gonzalez-Juarbe, Ashleigh N. Riegler, Alexander S. Jureka, Ryan P. Gilley, Jeffrey D. Brand, John E. Trombley, Ninecia R. Scott, Maryann P. Platt, Peter H. Dube, Chad M. Petit, Kevin S. Harrod, Carlos J. Orihuela

Research output: Contribution to journalArticle

Abstract

Gonzalez-Juarbe et al. identify necroptosis as a pathway modulating disease severity during secondary bacterial infection (SBI) following influenza virus infection. They show that influenza-virus-induced oxidative stress is required to sensitize pulmonary cells to the pro-necroptotic activity of bacterial pore-forming toxins, providing a mechanism to explain the necrosis observed during SBI.

Original languageEnglish (US)
Article number108062
JournalCell Reports
Volume32
Issue number8
DOIs
StatePublished - Aug 25 2020

Keywords

  • Streptococcus pneumoniae
  • cell death
  • co-infections
  • epithelial cells
  • inflammation
  • influenza A virus
  • necroptosis
  • oxidative stress
  • pneumonia
  • secondary bacterial infection

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Gonzalez-Juarbe, N., Riegler, A. N., Jureka, A. S., Gilley, R. P., Brand, J. D., Trombley, J. E., Scott, N. R., Platt, M. P., Dube, P. H., Petit, C. M., Harrod, K. S., & Orihuela, C. J. (2020). Influenza-Induced Oxidative Stress Sensitizes Lung Cells to Bacterial-Toxin-Mediated Necroptosis. Cell Reports, 32(8), [108062]. https://doi.org/10.1016/j.celrep.2020.108062