Influence of Variations in CCL3L1 and CCR5 on Tuberculosis in a Northwestern Colombian Population

Manju Mamtani; Srinivas Mummidi; Veron Ramsuran; Minh Hieu Pham; Robert Maldonado; Kazi Begum; Maria Soledad Valera; Racquel Sanchez; John Castiblanco; Hemant Kulkarni; Thumbi Ndung'u; Weijing He; Juan Manuel Anaya; Sunil K. Ahuja

doi:10.1093/infdis/jir145

Influence of Variations in CCL3L1 and CCR5 on Tuberculosis in a Northwestern Colombian Population

Manju Mamtani
, Srinivas Mummidi
, Veron Ramsuran
, Minh Hieu Pham
, Robert Maldonado
, Kazi Begum
, Maria Soledad Valera
, Racquel Sanchez
, John Castiblanco
, Hemant Kulkarni
, Thumbi Ndung'u
, Weijing He
, Juan Manuel Anaya
, Sunil K. Ahuja

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

We investigated the association of polymorphisms in CCR5, the major human immunodeficiency virus (HIV)-1 coreceptor, and copy number of its potent ligand CCL3L1 with tuberculosis in 298 individuals from Colombia. The CCR5-HHD haplotype, a known genetic determinant of increased susceptibility to HIV-AIDS, and a high copy number of CCL3L1, a known genetic determinant of enhanced CCL3/CCL3L1 chemokine expression, each associated with presence of tuberculosis. Furthermore, CCR5-HHD was associated with higher CCR5 gene and surface expression. These results substantiate the strong link between the proinflammatory effects of CCR5 and its ligands with active tuberculosis and suggest that chemokine-chemokine receptor genetic determinants may influence tuberculosis in addition to HIV/AIDS.

Original language	English (US)
Pages (from-to)	1590-1594
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	203
Issue number	11
DOIs	https://doi.org/10.1093/infdis/jir145
State	Published - Jun 1 2011

ASJC Scopus subject areas

General Medicine

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10.1093/infdis/jir145

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Mamtani, M., Mummidi, S., Ramsuran, V., Pham, M. H., Maldonado, R., Begum, K., Valera, M. S., Sanchez, R., Castiblanco, J., Kulkarni, H., Ndung'u, T., He, W., Anaya, J. M., & Ahuja, S. K. (2011). Influence of Variations in CCL3L1 and CCR5 on Tuberculosis in a Northwestern Colombian Population. Journal of Infectious Diseases, 203(11), 1590-1594. https://doi.org/10.1093/infdis/jir145

Mamtani, M, Mummidi, S, Ramsuran, V, Pham, MH, Maldonado, R, Begum, K, Valera, MS, Sanchez, R, Castiblanco, J, Kulkarni, H, Ndung'u, T, He, W, Anaya, JM & Ahuja, SK 2011, 'Influence of Variations in CCL3L1 and CCR5 on Tuberculosis in a Northwestern Colombian Population', Journal of Infectious Diseases, vol. 203, no. 11, pp. 1590-1594. https://doi.org/10.1093/infdis/jir145

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title = "Influence of Variations in CCL3L1 and CCR5 on Tuberculosis in a Northwestern Colombian Population",

abstract = "We investigated the association of polymorphisms in CCR5, the major human immunodeficiency virus (HIV)-1 coreceptor, and copy number of its potent ligand CCL3L1 with tuberculosis in 298 individuals from Colombia. The CCR5-HHD haplotype, a known genetic determinant of increased susceptibility to HIV-AIDS, and a high copy number of CCL3L1, a known genetic determinant of enhanced CCL3/CCL3L1 chemokine expression, each associated with presence of tuberculosis. Furthermore, CCR5-HHD was associated with higher CCR5 gene and surface expression. These results substantiate the strong link between the proinflammatory effects of CCR5 and its ligands with active tuberculosis and suggest that chemokine-chemokine receptor genetic determinants may influence tuberculosis in addition to HIV/AIDS.",

author = "Manju Mamtani and Srinivas Mummidi and Veron Ramsuran and Pham, \{Minh Hieu\} and Robert Maldonado and Kazi Begum and Valera, \{Maria Soledad\} and Racquel Sanchez and John Castiblanco and Hemant Kulkarni and Thumbi Ndung'u and Weijing He and Anaya, \{Juan Manuel\} and Ahuja, \{Sunil K.\}",

note = "Funding Information: This work was supported by the Veterans Administration Center on AIDS and HIV infection of the South Texas Veterans Health Care System, and the NIH (R37046326), a VA MERIT award, the Elizabeth Glaser Scientist Award, the Burroughs Wellcome Clinical Scientist Award in Translational Research, and the Doris Duke Distinguished Clinical Scientist Award to S. K. A. The work was also supported by a VA MERIT award to S. M.",

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AU - Maldonado, Robert

AU - Begum, Kazi

AU - Valera, Maria Soledad

AU - Sanchez, Racquel

AU - Castiblanco, John

AU - Kulkarni, Hemant

AU - Ndung'u, Thumbi

AU - He, Weijing

AU - Anaya, Juan Manuel

AU - Ahuja, Sunil K.

N1 - Funding Information: This work was supported by the Veterans Administration Center on AIDS and HIV infection of the South Texas Veterans Health Care System, and the NIH (R37046326), a VA MERIT award, the Elizabeth Glaser Scientist Award, the Burroughs Wellcome Clinical Scientist Award in Translational Research, and the Doris Duke Distinguished Clinical Scientist Award to S. K. A. The work was also supported by a VA MERIT award to S. M.

PY - 2011/6/1

Y1 - 2011/6/1

N2 - We investigated the association of polymorphisms in CCR5, the major human immunodeficiency virus (HIV)-1 coreceptor, and copy number of its potent ligand CCL3L1 with tuberculosis in 298 individuals from Colombia. The CCR5-HHD haplotype, a known genetic determinant of increased susceptibility to HIV-AIDS, and a high copy number of CCL3L1, a known genetic determinant of enhanced CCL3/CCL3L1 chemokine expression, each associated with presence of tuberculosis. Furthermore, CCR5-HHD was associated with higher CCR5 gene and surface expression. These results substantiate the strong link between the proinflammatory effects of CCR5 and its ligands with active tuberculosis and suggest that chemokine-chemokine receptor genetic determinants may influence tuberculosis in addition to HIV/AIDS.

AB - We investigated the association of polymorphisms in CCR5, the major human immunodeficiency virus (HIV)-1 coreceptor, and copy number of its potent ligand CCL3L1 with tuberculosis in 298 individuals from Colombia. The CCR5-HHD haplotype, a known genetic determinant of increased susceptibility to HIV-AIDS, and a high copy number of CCL3L1, a known genetic determinant of enhanced CCL3/CCL3L1 chemokine expression, each associated with presence of tuberculosis. Furthermore, CCR5-HHD was associated with higher CCR5 gene and surface expression. These results substantiate the strong link between the proinflammatory effects of CCR5 and its ligands with active tuberculosis and suggest that chemokine-chemokine receptor genetic determinants may influence tuberculosis in addition to HIV/AIDS.

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Influence of Variations in CCL3L1 and CCR5 on Tuberculosis in a Northwestern Colombian Population

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