Influence of Variations in CCL3L1 and CCR5 on Tuberculosis in a Northwestern Colombian Population

Manju Mamtani, Srinivas Mummidi, Veron Ramsuran, Minh Hieu Pham, Robert Maldonado, Kazi Begum, Maria Soledad Valera, Racquel Sanchez, John Castiblanco, Hemant Kulkarni, Thumbi Ndung'u, Weijing He, Juan Manuel Anaya, Sunil K. Ahuja

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

We investigated the association of polymorphisms in CCR5, the major human immunodeficiency virus (HIV)-1 coreceptor, and copy number of its potent ligand CCL3L1 with tuberculosis in 298 individuals from Colombia. The CCR5-HHD haplotype, a known genetic determinant of increased susceptibility to HIV-AIDS, and a high copy number of CCL3L1, a known genetic determinant of enhanced CCL3/CCL3L1 chemokine expression, each associated with presence of tuberculosis. Furthermore, CCR5-HHD was associated with higher CCR5 gene and surface expression. These results substantiate the strong link between the proinflammatory effects of CCR5 and its ligands with active tuberculosis and suggest that chemokine-chemokine receptor genetic determinants may influence tuberculosis in addition to HIV/AIDS.

Original languageEnglish (US)
Pages (from-to)1590-1594
Number of pages5
JournalJournal of Infectious Diseases
Volume203
Issue number11
DOIs
StatePublished - Jun 1 2011

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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