Influence of T cell specificity on the antibody response to the acetylcholine receptor

Keith A. Krolick, Olgui E. Urso

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Lymph node T cells were obtained from rats immunized with purified acetylcholine receptor (AChR) or isolated receptor subunits (α, β, γ, or σ). The immune T cells were then analyzed for their ability to respond to native AChR or AChR subunit challenge in an in vitro proliferation assay, as well as to perform as helper T cells (TH) in an in vitro anti-AChR antibody response. Results indicated a significant degree of subunit-to-subunit crossreactivity at the T cell level. Moreover, helper function could be generated by stimulation of T cells immune to any of the AChR subunits, although α-immune TH cells appeared to provide a quantifiably increased level of specific antibody production by AChR-immune B cells in vitro when compared to antibody produced by the same B cells in conjunction when β-, γ-, or σ-immune TH cells.

Original languageEnglish (US)
Pages (from-to)75-87
Number of pages13
JournalJournal of Neuroimmunology
Volume13
Issue number1
DOIs
StatePublished - Nov 1986

Keywords

  • Acetylcholine receptor
  • Autoimmunity
  • Myasthenia gravis
  • T cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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