Influence of pregnancy on the hepatic metabolism of parathion

S. D. Weitman, M. J. Vodicnik, J. J. Lech

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The effect of pregnancy on the hepatic metabolism of parathion was examined. The in vitro rate of hepatic microsomal activation of parathion to paraoxon was significantly reduced in mice at 19 days of gestation when compared to nonpregnant controls. Total hepatic metabolism of parathion was determined during in situ perfusion of livers from pregnant and nonpregnant mice. Levels of parathion, paraoxon, and p-nitrophenol in the perfusate after 45 min of perfusion did not differ significantly between livers from the pregnant and nonpregnant groups. These data indicate that total hepatic metabolism of these three compounds is not altered in pregnancy despite a decrease in specific activity for parathion activation.

Original languageEnglish (US)
Pages (from-to)23-31
Number of pages9
JournalDevelopmental Pharmacology and Therapeutics
Volume9
Issue number1
DOIs
StatePublished - Jan 1 1986
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

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