TY - JOUR
T1 - Influence of periodontal treatment on rheumatoid arthritis
T2 - a systematic review and meta‐analysis
AU - Calderaro, Débora Cerqueira
AU - Corrêa, Jôice Dias
AU - Ferreira, Gilda Aparecida
AU - Barbosa, Izabela Guimarães
AU - Martins, Carolina Castro
AU - Silva, Tarcília Aparecida
AU - Teixeira, Antônio Lúcio
N1 - Publisher Copyright:
© 2016
PY - 2017/5
Y1 - 2017/5
N2 - Objective To evaluate the influence of periodontal treatment on rheumatoid arthritis activity. Methods MEDLINE/PUBMED, The Cochrane Library, Clinical Trials, SciELO and LILACS were searched for studies published until December 2014. Included articles were: prospective studies; including patients older than 18 years, diagnosed with periodontitis and rheumatoid arthritis submitted to non‐surgical periodontal treatment; with a control group receiving no periodontal treatment; with outcomes including at least one marker of rheumatoid arthritis activity. Methodological quality of the studies was assessed using PEDro scale. Quantitative data were pooled in statistical meta‐analysis using Review Manager 5. Results Four articles were included. Non‐surgical periodontal treatment was associated with a significant reduction of DAS28 (OR: −1.18; 95% CI: −1.43, −0.93; p <0.00001). Erythrocyte sedimentation rate, C‐reactive protein, patient's assessment of rheumatoid activity using visual analogical scale, tender and swollen joint counts showed a trend towards reduction (not statistically significant). Conclusions The reduction of DAS 28 in patients with rheumatoid arthritis after periodontal treatment suggests that the improvement of periodontal condition is beneficial to these patients. Further randomized controlled clinical trials are necessary to confirm this finding.
AB - Objective To evaluate the influence of periodontal treatment on rheumatoid arthritis activity. Methods MEDLINE/PUBMED, The Cochrane Library, Clinical Trials, SciELO and LILACS were searched for studies published until December 2014. Included articles were: prospective studies; including patients older than 18 years, diagnosed with periodontitis and rheumatoid arthritis submitted to non‐surgical periodontal treatment; with a control group receiving no periodontal treatment; with outcomes including at least one marker of rheumatoid arthritis activity. Methodological quality of the studies was assessed using PEDro scale. Quantitative data were pooled in statistical meta‐analysis using Review Manager 5. Results Four articles were included. Non‐surgical periodontal treatment was associated with a significant reduction of DAS28 (OR: −1.18; 95% CI: −1.43, −0.93; p <0.00001). Erythrocyte sedimentation rate, C‐reactive protein, patient's assessment of rheumatoid activity using visual analogical scale, tender and swollen joint counts showed a trend towards reduction (not statistically significant). Conclusions The reduction of DAS 28 in patients with rheumatoid arthritis after periodontal treatment suggests that the improvement of periodontal condition is beneficial to these patients. Further randomized controlled clinical trials are necessary to confirm this finding.
KW - Meta‐analysis
KW - Periodontal‐systemic disease interactions
KW - Periodontitis
KW - Rheumatoid arthritis
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U2 - 10.1016/j.rbr.2016.10.002
DO - 10.1016/j.rbr.2016.10.002
M3 - Short survey
AN - SCOPUS:85019387409
SN - 0482-5004
VL - 57
SP - 238
EP - 244
JO - Revista Brasileira de Reumatologia
JF - Revista Brasileira de Reumatologia
IS - 3
ER -