Influence of periodontal treatment on rheumatoid arthritis: a systematic review and meta‐analysis

Débora Cerqueira Calderaro, Jôice Dias Corrêa, Gilda Aparecida Ferreira, Izabela Guimarães Barbosa, Carolina Castro Martins, Tarcília Aparecida Silva, Antônio Lúcio Teixeira

Research output: Contribution to journalShort surveypeer-review

28 Scopus citations


Objective To evaluate the influence of periodontal treatment on rheumatoid arthritis activity. Methods MEDLINE/PUBMED, The Cochrane Library, Clinical Trials, SciELO and LILACS were searched for studies published until December 2014. Included articles were: prospective studies; including patients older than 18 years, diagnosed with periodontitis and rheumatoid arthritis submitted to non‐surgical periodontal treatment; with a control group receiving no periodontal treatment; with outcomes including at least one marker of rheumatoid arthritis activity. Methodological quality of the studies was assessed using PEDro scale. Quantitative data were pooled in statistical meta‐analysis using Review Manager 5. Results Four articles were included. Non‐surgical periodontal treatment was associated with a significant reduction of DAS28 (OR: −1.18; 95% CI: −1.43, −0.93; p <0.00001). Erythrocyte sedimentation rate, C‐reactive protein, patient's assessment of rheumatoid activity using visual analogical scale, tender and swollen joint counts showed a trend towards reduction (not statistically significant). Conclusions The reduction of DAS 28 in patients with rheumatoid arthritis after periodontal treatment suggests that the improvement of periodontal condition is beneficial to these patients. Further randomized controlled clinical trials are necessary to confirm this finding.

Original languageEnglish (US)
Pages (from-to)238-244
Number of pages7
JournalRevista Brasileira de Reumatologia
Issue number3
StatePublished - May 2017
Externally publishedYes


  • Meta‐analysis
  • Periodontal‐systemic disease interactions
  • Periodontitis
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Rheumatology


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