Influence of particle size on regional lung deposition - What evidence is there?

Robert O. Williams, Thiago C. Carvalho, Jay I. Peters

Research output: Contribution to journalReview article

243 Scopus citations

Abstract

The understanding of deposition of particles in the respiratory tract is of great value to risk assessment of inhalation toxicology and to improve efficiency in drug delivery of inhalation therapies. There are three main basic mechanisms of particle deposition based primarily on particle size: inertial impaction, sedimentation and diffusion. The regional deposition in the lungs can be evaluated in regards to the aerodynamic particle size, in which particle density plays a significant role. In this review paper, we first introduce the available imaging techniques to confirm regional deposition of particles in the human respiratory tract, such as planar scintigraphy, single photon emission computed tomography (SPECT) and positron emission tomography (PET). These technologies have widely advanced and consequently benefited the understanding of deposition pattern, although there is a lack of lung dosimetry techniques to evaluate the deposition of nanoparticles. Subsequently, we present a comprehensive review summarizing the evidence available in the literature that confirms the deposition of smaller particles in the smaller airways as opposed to the larger airways.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalInternational Journal of Pharmaceutics
Volume406
Issue number1-2
DOIs
StatePublished - Mar 15 2011

Keywords

  • Aerodynamic diameter
  • Imaging techniques
  • Inhalation therapy
  • Particle size distribution
  • Regional lung deposition

ASJC Scopus subject areas

  • Pharmaceutical Science

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