Influence of melatonin, 5-Methoxytryptophol and pinealectomy on pituitary and plasma gonadotropin and prolactin levels in castrated adult male rats

Judy A. Talbot, R. J. Reiter

Research output: Contribution to journalArticle

19 Scopus citations


The effects of melatonin, 5-methoxytryptophol and pinealectomy on pituitary and plasma LH, FSH and prolactin levels were investigated in adult male castrated rats. Melatonin and 5-methoxytryptophol were mixed with beeswax (1:24) and a 25-mg pellet was implanted sub-cutaneously each week. Castration-induced rises in pituitary and plasma LH levels were not influenced by either treatment with melatonin or 5-methoxytryptophol, or by pinealectomy. 5-Methoxytryptophol, but not melatonin or pineal removal, lowered pituitary and plasma FSH levels in castrated rats. Castration did not induce rises in plasma prolactin; however, because of the hypertrophied pituitaries, they contained larger total amounts of prolactin. This was further augmented by 5-methoxytryptophol.

Original languageEnglish (US)
Pages (from-to)164-172
Number of pages9
Issue number3
StatePublished - Jan 1 1973



  • 5-Methoxytryptophol
  • Castration
  • Follicle stimulating hormone (FSH)
  • Luteinizing hormone (LH)
  • Melatonin
  • Pineal gland
  • Prolactin

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

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