Influence of melatonin, 5-Methoxytryptophol and pinealectomy on pituitary and plasma gonadotropin and prolactin levels in castrated adult male rats

Judy A. Talbot; R. J. Reiter

doi:10.1159/000122234

Influence of melatonin, 5-Methoxytryptophol and pinealectomy on pituitary and plasma gonadotropin and prolactin levels in castrated adult male rats

Judy A. Talbot, R. J. Reiter

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

The effects of melatonin, 5-methoxytryptophol and pinealectomy on pituitary and plasma LH, FSH and prolactin levels were investigated in adult male castrated rats. Melatonin and 5-methoxytryptophol were mixed with beeswax (1:24) and a 25-mg pellet was implanted sub-cutaneously each week. Castration-induced rises in pituitary and plasma LH levels were not influenced by either treatment with melatonin or 5-methoxytryptophol, or by pinealectomy. 5-Methoxytryptophol, but not melatonin or pineal removal, lowered pituitary and plasma FSH levels in castrated rats. Castration did not induce rises in plasma prolactin; however, because of the hypertrophied pituitaries, they contained larger total amounts of prolactin. This was further augmented by 5-methoxytryptophol.

Original language	English (US)
Pages (from-to)	164-172
Number of pages	9
Journal	Neuroendocrinology
Volume	13
Issue number	3
DOIs	https://doi.org/10.1159/000122234
State	Published - Jan 1 1973
Externally published	Yes

Keywords

5-Methoxytryptophol
Castration
Follicle stimulating hormone (FSH)
Luteinizing hormone (LH)
Melatonin
Pineal gland
Prolactin

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology
Endocrine and Autonomic Systems
Cellular and Molecular Neuroscience

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title = "Influence of melatonin, 5-Methoxytryptophol and pinealectomy on pituitary and plasma gonadotropin and prolactin levels in castrated adult male rats",

abstract = "The effects of melatonin, 5-methoxytryptophol and pinealectomy on pituitary and plasma LH, FSH and prolactin levels were investigated in adult male castrated rats. Melatonin and 5-methoxytryptophol were mixed with beeswax (1:24) and a 25-mg pellet was implanted sub-cutaneously each week. Castration-induced rises in pituitary and plasma LH levels were not influenced by either treatment with melatonin or 5-methoxytryptophol, or by pinealectomy. 5-Methoxytryptophol, but not melatonin or pineal removal, lowered pituitary and plasma FSH levels in castrated rats. Castration did not induce rises in plasma prolactin; however, because of the hypertrophied pituitaries, they contained larger total amounts of prolactin. This was further augmented by 5-methoxytryptophol.",

keywords = "5-Methoxytryptophol, Castration, Follicle stimulating hormone (FSH), Luteinizing hormone (LH), Melatonin, Pineal gland, Prolactin",

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AU - Reiter, R. J.

PY - 1973/1/1

Y1 - 1973/1/1

N2 - The effects of melatonin, 5-methoxytryptophol and pinealectomy on pituitary and plasma LH, FSH and prolactin levels were investigated in adult male castrated rats. Melatonin and 5-methoxytryptophol were mixed with beeswax (1:24) and a 25-mg pellet was implanted sub-cutaneously each week. Castration-induced rises in pituitary and plasma LH levels were not influenced by either treatment with melatonin or 5-methoxytryptophol, or by pinealectomy. 5-Methoxytryptophol, but not melatonin or pineal removal, lowered pituitary and plasma FSH levels in castrated rats. Castration did not induce rises in plasma prolactin; however, because of the hypertrophied pituitaries, they contained larger total amounts of prolactin. This was further augmented by 5-methoxytryptophol.

AB - The effects of melatonin, 5-methoxytryptophol and pinealectomy on pituitary and plasma LH, FSH and prolactin levels were investigated in adult male castrated rats. Melatonin and 5-methoxytryptophol were mixed with beeswax (1:24) and a 25-mg pellet was implanted sub-cutaneously each week. Castration-induced rises in pituitary and plasma LH levels were not influenced by either treatment with melatonin or 5-methoxytryptophol, or by pinealectomy. 5-Methoxytryptophol, but not melatonin or pineal removal, lowered pituitary and plasma FSH levels in castrated rats. Castration did not induce rises in plasma prolactin; however, because of the hypertrophied pituitaries, they contained larger total amounts of prolactin. This was further augmented by 5-methoxytryptophol.

KW - 5-Methoxytryptophol

KW - Castration

KW - Follicle stimulating hormone (FSH)

KW - Luteinizing hormone (LH)

KW - Melatonin

KW - Pineal gland

KW - Prolactin

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JO - Neuroendocrinology

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Influence of melatonin, 5-Methoxytryptophol and pinealectomy on pituitary and plasma gonadotropin and prolactin levels in castrated adult male rats

Abstract

Keywords

ASJC Scopus subject areas

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