The effects of melatonin, 5-methoxytryptophol and pinealectomy on pituitary and plasma LH, FSH and prolactin levels were investigated in adult male castrated rats. Melatonin and 5-methoxytryptophol were mixed with beeswax (1:24) and a 25-mg pellet was implanted sub-cutaneously each week. Castration-induced rises in pituitary and plasma LH levels were not influenced by either treatment with melatonin or 5-methoxytryptophol, or by pinealectomy. 5-Methoxytryptophol, but not melatonin or pineal removal, lowered pituitary and plasma FSH levels in castrated rats. Castration did not induce rises in plasma prolactin; however, because of the hypertrophied pituitaries, they contained larger total amounts of prolactin. This was further augmented by 5-methoxytryptophol.
- Follicle stimulating hormone (FSH)
- Luteinizing hormone (LH)
- Pineal gland
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Endocrine and Autonomic Systems
- Cellular and Molecular Neuroscience