Abstract
The effects of melatonin, 5-methoxytryptophol and pinealectomy on pituitary and plasma LH, FSH and prolactin levels were investigated in adult male castrated rats. Melatonin and 5-methoxytryptophol were mixed with beeswax (1:24) and a 25-mg pellet was implanted sub-cutaneously each week. Castration-induced rises in pituitary and plasma LH levels were not influenced by either treatment with melatonin or 5-methoxytryptophol, or by pinealectomy. 5-Methoxytryptophol, but not melatonin or pineal removal, lowered pituitary and plasma FSH levels in castrated rats. Castration did not induce rises in plasma prolactin; however, because of the hypertrophied pituitaries, they contained larger total amounts of prolactin. This was further augmented by 5-methoxytryptophol.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 164-172 |
| Number of pages | 9 |
| Journal | Neuroendocrinology |
| Volume | 13 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jan 1 1973 |
| Externally published | Yes |
Keywords
- 5-Methoxytryptophol
- Castration
- Follicle stimulating hormone (FSH)
- Luteinizing hormone (LH)
- Melatonin
- Pineal gland
- Prolactin
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Endocrinology
- Endocrine and Autonomic Systems
- Cellular and Molecular Neuroscience