Influence of hormones on the release of iron by macrophages

A major factor in the pathogenesis of the anemia of chronic disease (ACD) is an impaired reutilization of hemoglobin iron, the reticuloendothelial (RE) block. Various agents have been reported to be useful in treating ACD. We report here the effects of certain of these agents on the release of iron from macrophages. Testosterone hydrogen succinate, sodium estrone glucuronide and dexamethasone phosphate increased the release of iron from macrophages, whereas erythropoietin had no effect on iron release. These findings support the concept of the RE block of iron release in the ACD. Agents which resolve the anemia also increase iron release by reticuloendothelial cells. This effect is independent of any erythropoietin-stimulating properties these agents may have in vivo.