TY - JOUR
T1 - Influence of cytokines and soluble receptors in the quality of life and functional capacity of workers exposed to silica
AU - Braz, Nayara Felicidade Tomaz
AU - Carneiro, Ana Paula Scalia
AU - De Avelar, Núbia Carelli Pereira
AU - De Miranda, Aline Silva
AU - Lacerda, Ana Cristina Rodrigues
AU - Teixeira, Mauro Martins
AU - Teixeira, Antônio Lúcio
AU - Mendonça, Vanessa Amaral
N1 - Publisher Copyright:
© 2016 American College of Occupational and Environmental Medicine.
PY - 2016/3/1
Y1 - 2016/3/1
N2 - Objectives: The aim of the study was to evaluate the plasma levels of inflammatory mediators in subjects exposed to silica, with and without silicosis compared with unexposed control group; and to check the association between inflammatory mediators with pulmonary function, quality of life, functional capacity, and dyspnea grade. Methods: Inflammatory mediators were measured by enzyme-linked immunosorbent assay. There were 30 subjects exposed to silica and 24 control group. Results: Interleukin-6 plasma levels were higher in subjects exposed to silica with and without silicosis than in the control group. There was a positive correlation between radiological severity and the quality of life, whereas there was a negative correlation between radiological severity and pulmonary function. A negative correlation between sTNFR1 plasma level and functional capacity was found. Interleukin-10 was negatively correlated with the quality of life total score and was positively correlated with the functional capacity and pulmonary function.
AB - Objectives: The aim of the study was to evaluate the plasma levels of inflammatory mediators in subjects exposed to silica, with and without silicosis compared with unexposed control group; and to check the association between inflammatory mediators with pulmonary function, quality of life, functional capacity, and dyspnea grade. Methods: Inflammatory mediators were measured by enzyme-linked immunosorbent assay. There were 30 subjects exposed to silica and 24 control group. Results: Interleukin-6 plasma levels were higher in subjects exposed to silica with and without silicosis than in the control group. There was a positive correlation between radiological severity and the quality of life, whereas there was a negative correlation between radiological severity and pulmonary function. A negative correlation between sTNFR1 plasma level and functional capacity was found. Interleukin-10 was negatively correlated with the quality of life total score and was positively correlated with the functional capacity and pulmonary function.
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U2 - 10.1097/JOM.0000000000000606
DO - 10.1097/JOM.0000000000000606
M3 - Article
C2 - 26949877
AN - SCOPUS:84963640883
SN - 1076-2752
VL - 58
SP - 272
EP - 276
JO - Journal of occupational and environmental medicine
JF - Journal of occupational and environmental medicine
IS - 3
ER -