Influence of breast and formula feeding on hepatic concentrations of apolipoprotein and low-density lipoprotein receptor mRNAs

Glen E. Mott, Leonard DeLallo, Donna M. Driscoll, C. Alex McMahan, Douglas S. Lewis

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

We tested the hypothesis that breast and formula feeding differentially affect hepatic mRNA concentrations for LDL receptor (LDL-R) and apolipoproteins A-I, B and E in infant baboons during the preweaning period. The mRNA concentrations were measured in liver biopsies obtained prior to weaning at 14 weeks from 43 baboons that were either breast-fed (n = 17) or fed formulas with a high (n = 12) or low (n = 14) polyunsaturated/saturated (P:S) fat ratio. Breast-fed baboons had 99% higher LDL-R mRNA concentrations compared with infants fed formulas, but there were no differences among breast and formula-fed baboons in mRNA concentrations of apolipoproteins A-I, B or E. The fatty acid P:S ratio of the formulas did not affect hepatic LDL-R or apolipoprotein mRNA concentrations. These results suggest that breast-feeding increases LDL-R gene expression even though breast milk is higher in cholesterol and saturated fat compared with formulas.

Original languageEnglish (US)
Pages (from-to)59-65
Number of pages7
JournalBiochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism
Volume1169
Issue number1
DOIs
StatePublished - Jul 21 1993

Keywords

  • (Nonhuman primate)
  • Apolipoprotein mRNA
  • Dietary fat
  • Infant nutrition
  • LDL receptor mRNA
  • Solution hybridization

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Endocrinology

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