Influence of arginine vasotocin on the estrogen-induced surge of LH and FSH in adult ovariectomized rats

David E. Blask; Mary K. Vaughan; Russel J. Reiter; Linda Y. Johnson

doi:10.1016/0024-3205(78)90663-X

Influence of arginine vasotocin on the estrogen-induced surge of LH and FSH in adult ovariectomized rats

David E. Blask, Mary K. Vaughan, Russel J. Reiter, Linda Y. Johnson

Department of Cell Systems & Anatomy

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The effects of arginine vasotocin (AVT) on the estrogen-induced surge of LH and FSH were examined in ovariectomized adult rats. Two and one-half weeks after ovariectomy, animals that were treated with a single subcutaneous (s.c.) dose of 5 μg of estradiol benzoate (EB) exhibited a surge of LH and FSH at 1700 and 1900 hours, respectively, two days after the administration of the EB. AVT, antidiuretic hormone (ADH) and oxytocin (OT) were administered s.c. in 1 μg dose every 4 hours beginning at 1500 hours on day 1 after EB treatment and then every 2 hours beginning at 1200 hours on day 2 after EB treatment. AVT completely prevented the LH surge at 1700 hours but was without effect on the FSH surge at 1900 hours on the day 2 after steroid treatment. Neither ADH nor OT had any significant effect on the afternoon surge of these hormones. It is postulated that AVT may interfere with the mechanisms mediating the estrogen-induced afternoon surge of LH in ovariectomized rats.

Original language	English (US)
Pages (from-to)	1035-1040
Number of pages	6
Journal	Life Sciences
Volume	23
Issue number	10
DOIs	https://doi.org/10.1016/0024-3205(78)90663-X
State	Published - Sep 11 1978

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/0024-3205(78)90663-X

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title = "Influence of arginine vasotocin on the estrogen-induced surge of LH and FSH in adult ovariectomized rats",

abstract = "The effects of arginine vasotocin (AVT) on the estrogen-induced surge of LH and FSH were examined in ovariectomized adult rats. Two and one-half weeks after ovariectomy, animals that were treated with a single subcutaneous (s.c.) dose of 5 μg of estradiol benzoate (EB) exhibited a surge of LH and FSH at 1700 and 1900 hours, respectively, two days after the administration of the EB. AVT, antidiuretic hormone (ADH) and oxytocin (OT) were administered s.c. in 1 μg dose every 4 hours beginning at 1500 hours on day 1 after EB treatment and then every 2 hours beginning at 1200 hours on day 2 after EB treatment. AVT completely prevented the LH surge at 1700 hours but was without effect on the FSH surge at 1900 hours on the day 2 after steroid treatment. Neither ADH nor OT had any significant effect on the afternoon surge of these hormones. It is postulated that AVT may interfere with the mechanisms mediating the estrogen-induced afternoon surge of LH in ovariectomized rats.",

author = "Blask, {David E.} and Vaughan, {Mary K.} and Reiter, {Russel J.} and Johnson, {Linda Y.}",

note = "Funding Information: It is generally believed that the positive feedback of estrogen at the level of the POA of the anterior hypothalamus is largely responsible for the preovulatory surge of the gonadotrophic hormones and subsequent ovulation (6,7, 8) . Osland et al . provided preliminary evidence suggesting that AVT might suppress the preovulatory surge of LH by acting at the medial POA or a higher lSupported in part by National Science Foundation Grant No . PCM 74-06276-A02 and NIH Grant No . P30HD10202 . Thanks are due to A . Moreno (Bioassay Core) for ex-cellent technical assistance .",

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AU - Blask, David E.

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AU - Johnson, Linda Y.

N1 - Funding Information: It is generally believed that the positive feedback of estrogen at the level of the POA of the anterior hypothalamus is largely responsible for the preovulatory surge of the gonadotrophic hormones and subsequent ovulation (6,7, 8) . Osland et al . provided preliminary evidence suggesting that AVT might suppress the preovulatory surge of LH by acting at the medial POA or a higher lSupported in part by National Science Foundation Grant No . PCM 74-06276-A02 and NIH Grant No . P30HD10202 . Thanks are due to A . Moreno (Bioassay Core) for ex-cellent technical assistance .

PY - 1978/9/11

Y1 - 1978/9/11

N2 - The effects of arginine vasotocin (AVT) on the estrogen-induced surge of LH and FSH were examined in ovariectomized adult rats. Two and one-half weeks after ovariectomy, animals that were treated with a single subcutaneous (s.c.) dose of 5 μg of estradiol benzoate (EB) exhibited a surge of LH and FSH at 1700 and 1900 hours, respectively, two days after the administration of the EB. AVT, antidiuretic hormone (ADH) and oxytocin (OT) were administered s.c. in 1 μg dose every 4 hours beginning at 1500 hours on day 1 after EB treatment and then every 2 hours beginning at 1200 hours on day 2 after EB treatment. AVT completely prevented the LH surge at 1700 hours but was without effect on the FSH surge at 1900 hours on the day 2 after steroid treatment. Neither ADH nor OT had any significant effect on the afternoon surge of these hormones. It is postulated that AVT may interfere with the mechanisms mediating the estrogen-induced afternoon surge of LH in ovariectomized rats.

AB - The effects of arginine vasotocin (AVT) on the estrogen-induced surge of LH and FSH were examined in ovariectomized adult rats. Two and one-half weeks after ovariectomy, animals that were treated with a single subcutaneous (s.c.) dose of 5 μg of estradiol benzoate (EB) exhibited a surge of LH and FSH at 1700 and 1900 hours, respectively, two days after the administration of the EB. AVT, antidiuretic hormone (ADH) and oxytocin (OT) were administered s.c. in 1 μg dose every 4 hours beginning at 1500 hours on day 1 after EB treatment and then every 2 hours beginning at 1200 hours on day 2 after EB treatment. AVT completely prevented the LH surge at 1700 hours but was without effect on the FSH surge at 1900 hours on the day 2 after steroid treatment. Neither ADH nor OT had any significant effect on the afternoon surge of these hormones. It is postulated that AVT may interfere with the mechanisms mediating the estrogen-induced afternoon surge of LH in ovariectomized rats.

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Influence of arginine vasotocin on the estrogen-induced surge of LH and FSH in adult ovariectomized rats

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