Influence of antiretroviral therapy on immunogenicity of simultaneous vaccinations against influenza, pneumococcal disease and hepatitis A and B in human immunodeficiency virus positive individuals

S. Horster, R. P. Laubender, L. Lehmeyer, D. P. Ankerst, J. Eberle, R. Reinert, M. Imöhl, M. van der Linden, B. Schweiger, J. R. Bogner

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Objectives: Immune response to many vaccinations is impaired in human immunodeficiency virus (HIV) positive patients. Methods: A total of n = 131 HIV positive patients were vaccinated against influenza, pneumococcal disease, hepatitis A and B, with n = 82 patients (62.6%) receiving 2 or more simultaneous vaccinations. Safety and immunogenicity of simultaneous vaccinations were assessed. Current antiretroviral therapy (ART) regimens were evaluated as potential predictors for antibody response. Results: Immune response rates were 45% (influenza), 68% (pneumococcus), 63.6% (hepatitis A) and 62.5% (hepatitis B). Adverse reactions after vaccination were documented in 2 of 131 patients (1.5%). No statistically significant difference between pre- and post-vaccination CD4+ T-cell counts (CD4) and HIV plasma load was observed. 85% of patients received ART containing nucleotide reverse transcriptase inhibitors, non-nucleotide reverse transcriptase inhibitors and/or protease inhibitors (PI). Higher ratio of CD4 to CD8 and intake of PI were statistically significant, independent predictors for antibody response after influenza vaccination (OR 1.9 and 2.8, p = 0.01 and 0.04, respectively). Conclusions: Simultaneous vaccinations in HIV positive patients were safe and well tolerated. The positive effect of PI on antibody response after influenza vaccination should be confirmed in larger studies.

Original languageEnglish (US)
Pages (from-to)484-491
Number of pages8
JournalJournal of Infection
Volume61
Issue number6
DOIs
StatePublished - Dec 1 2010

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Keywords

  • HIV
  • Influenza
  • Protease inhibitor
  • Vaccination

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Horster, S., Laubender, R. P., Lehmeyer, L., Ankerst, D. P., Eberle, J., Reinert, R., Imöhl, M., van der Linden, M., Schweiger, B., & Bogner, J. R. (2010). Influence of antiretroviral therapy on immunogenicity of simultaneous vaccinations against influenza, pneumococcal disease and hepatitis A and B in human immunodeficiency virus positive individuals. Journal of Infection, 61(6), 484-491. https://doi.org/10.1016/j.jinf.2010.09.030