Abstract
To compare the clinical outcomes of older (age ≥55 years) non-Hodgkin lymphoma (NHL) patients with younger NHL patients (<55 years) receiving autologous hematopoietic cell transplantation (HCT) while adjusting for patient-, disease-, and treatment-related variables, we compared autologous HCT outcomes in 805 NHL patients aged ≥55 years to 1949 NHL patients <55 years during the years 1990-2000 using data reported to the Center for International Blood and Marrow Transplant Research (CIBMTR). In multivariate analysis, older patients with aggressive histologies were 1.86 times (95% confidence interval [CI] 1.43-2.43, P < .001) more likely than younger patients to experience treatment-related mortality (TRM). Relative death risks were 1.33 times (CI 1.04-1.71, P = .024) and 1.50 times (CI 1.33-16.9, P < .001) higher in older compared to younger patients with follicular grade I/II and aggressive histologies, respectively. Autologous HCT in older NHL patients is feasible, but most disease-related outcomes are statistically inferior to younger patients. Studies addressing supportive care particular to older patients, who are most likely to benefit from this approach, are recommended.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1323-1333 |
| Number of pages | 11 |
| Journal | Biology of Blood and Marrow Transplantation |
| Volume | 14 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 2008 |
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Keywords
- Autologous HCT
- Elderly
- Non-Hodgkin lymphoma
- Relapse
- Second complete remission
ASJC Scopus subject areas
- Transplantation
- Hematology
Cite this
Influence of Age and Histology on Outcome in Adult Non-Hodgkin Lymphoma Patients Undergoing Autologous Hematopoietic Cell Transplantation (HCT) : A Report from The Center For International Blood & Marrow Transplant Research (CIBMTR). / Lazarus, Hillard M.; Carreras, Jeanette; Boudreau, Christian; Loberiza, Fausto R.; Armitage, James O.; Bolwell, Brian J.; Freytes, César O.; Gale, Robert Peter; Gibson, John; Hale, Gregory A.; Inwards, David J.; LeMaistre, Charles F.; Maharaj, Dipnarine; Marks, David I.; Miller, Alan M.; Pavlovsky, Santiago; Schouten, Harry C.; van Besien, Koen; Vose, Julie M.; Bitran, Jacob D.; Khouri, Issa F.; McCarthy, Philip L.; Yu, Hongmei; Rowlings, Philip; Serna, Derek S.; Horowitz, Mary M.; Rizzo, J. Douglas.
In: Biology of Blood and Marrow Transplantation, Vol. 14, No. 12, 12.2008, p. 1323-1333.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Influence of Age and Histology on Outcome in Adult Non-Hodgkin Lymphoma Patients Undergoing Autologous Hematopoietic Cell Transplantation (HCT)
T2 - A Report from The Center For International Blood & Marrow Transplant Research (CIBMTR)
AU - Lazarus, Hillard M.
AU - Carreras, Jeanette
AU - Boudreau, Christian
AU - Loberiza, Fausto R.
AU - Armitage, James O.
AU - Bolwell, Brian J.
AU - Freytes, César O.
AU - Gale, Robert Peter
AU - Gibson, John
AU - Hale, Gregory A.
AU - Inwards, David J.
AU - LeMaistre, Charles F.
AU - Maharaj, Dipnarine
AU - Marks, David I.
AU - Miller, Alan M.
AU - Pavlovsky, Santiago
AU - Schouten, Harry C.
AU - van Besien, Koen
AU - Vose, Julie M.
AU - Bitran, Jacob D.
AU - Khouri, Issa F.
AU - McCarthy, Philip L.
AU - Yu, Hongmei
AU - Rowlings, Philip
AU - Serna, Derek S.
AU - Horowitz, Mary M.
AU - Rizzo, J. Douglas
PY - 2008/12
Y1 - 2008/12
N2 - To compare the clinical outcomes of older (age ≥55 years) non-Hodgkin lymphoma (NHL) patients with younger NHL patients (<55 years) receiving autologous hematopoietic cell transplantation (HCT) while adjusting for patient-, disease-, and treatment-related variables, we compared autologous HCT outcomes in 805 NHL patients aged ≥55 years to 1949 NHL patients <55 years during the years 1990-2000 using data reported to the Center for International Blood and Marrow Transplant Research (CIBMTR). In multivariate analysis, older patients with aggressive histologies were 1.86 times (95% confidence interval [CI] 1.43-2.43, P < .001) more likely than younger patients to experience treatment-related mortality (TRM). Relative death risks were 1.33 times (CI 1.04-1.71, P = .024) and 1.50 times (CI 1.33-16.9, P < .001) higher in older compared to younger patients with follicular grade I/II and aggressive histologies, respectively. Autologous HCT in older NHL patients is feasible, but most disease-related outcomes are statistically inferior to younger patients. Studies addressing supportive care particular to older patients, who are most likely to benefit from this approach, are recommended.
AB - To compare the clinical outcomes of older (age ≥55 years) non-Hodgkin lymphoma (NHL) patients with younger NHL patients (<55 years) receiving autologous hematopoietic cell transplantation (HCT) while adjusting for patient-, disease-, and treatment-related variables, we compared autologous HCT outcomes in 805 NHL patients aged ≥55 years to 1949 NHL patients <55 years during the years 1990-2000 using data reported to the Center for International Blood and Marrow Transplant Research (CIBMTR). In multivariate analysis, older patients with aggressive histologies were 1.86 times (95% confidence interval [CI] 1.43-2.43, P < .001) more likely than younger patients to experience treatment-related mortality (TRM). Relative death risks were 1.33 times (CI 1.04-1.71, P = .024) and 1.50 times (CI 1.33-16.9, P < .001) higher in older compared to younger patients with follicular grade I/II and aggressive histologies, respectively. Autologous HCT in older NHL patients is feasible, but most disease-related outcomes are statistically inferior to younger patients. Studies addressing supportive care particular to older patients, who are most likely to benefit from this approach, are recommended.
KW - Autologous HCT
KW - Elderly
KW - Non-Hodgkin lymphoma
KW - Relapse
KW - Second complete remission
UR - http://www.scopus.com/inward/record.url?scp=56749184062&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=56749184062&partnerID=8YFLogxK
U2 - 10.1016/j.bbmt.2008.09.008
DO - 10.1016/j.bbmt.2008.09.008
M3 - Article
C2 - 19041053
AN - SCOPUS:56749184062
VL - 14
SP - 1323
EP - 1333
JO - Biology of Blood and Marrow Transplantation
JF - Biology of Blood and Marrow Transplantation
SN - 1083-8791
IS - 12
ER -