Influence of Age and Histology on Outcome in Adult Non-Hodgkin Lymphoma Patients Undergoing Autologous Hematopoietic Cell Transplantation (HCT): A Report from The Center For International Blood & Marrow Transplant Research (CIBMTR)

Hillard M. Lazarus, Jeanette Carreras, Christian Boudreau, Fausto R. Loberiza, James O. Armitage, Brian J. Bolwell, César O. Freytes, Robert Peter Gale, John Gibson, Gregory A. Hale, David J. Inwards, Charles F. LeMaistre, Dipnarine Maharaj, David I. Marks, Alan M. Miller, Santiago Pavlovsky, Harry C. Schouten, Koen van Besien, Julie M. Vose, Jacob D. BitranIssa F. Khouri, Philip L. McCarthy, Hongmei Yu, Philip Rowlings, Derek S. Serna, Mary M. Horowitz, J. Douglas Rizzo

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

To compare the clinical outcomes of older (age ≥55 years) non-Hodgkin lymphoma (NHL) patients with younger NHL patients (<55 years) receiving autologous hematopoietic cell transplantation (HCT) while adjusting for patient-, disease-, and treatment-related variables, we compared autologous HCT outcomes in 805 NHL patients aged ≥55 years to 1949 NHL patients <55 years during the years 1990-2000 using data reported to the Center for International Blood and Marrow Transplant Research (CIBMTR). In multivariate analysis, older patients with aggressive histologies were 1.86 times (95% confidence interval [CI] 1.43-2.43, P < .001) more likely than younger patients to experience treatment-related mortality (TRM). Relative death risks were 1.33 times (CI 1.04-1.71, P = .024) and 1.50 times (CI 1.33-16.9, P < .001) higher in older compared to younger patients with follicular grade I/II and aggressive histologies, respectively. Autologous HCT in older NHL patients is feasible, but most disease-related outcomes are statistically inferior to younger patients. Studies addressing supportive care particular to older patients, who are most likely to benefit from this approach, are recommended.

Original languageEnglish (US)
Pages (from-to)1323-1333
Number of pages11
JournalBiology of Blood and Marrow Transplantation
Volume14
Issue number12
DOIs
StatePublished - Dec 2008

Keywords

  • Autologous HCT
  • Elderly
  • Non-Hodgkin lymphoma
  • Relapse
  • Second complete remission

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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