INFLUENCE OF A STEADY LAMINAR SHEAR STRESS ON THE INTERNALIZATION OF LOW DENSITY LIPOPROTEINS BY CULTURED BOVINE AORTIC ENDOTHELIAL CELLS.

Bernd Steinbach; Eugene Sprague; Colin Schwartz; Robert Nerem

INFLUENCE OF A STEADY LAMINAR SHEAR STRESS ON THE INTERNALIZATION OF LOW DENSITY LIPOPROTEINS BY CULTURED BOVINE AORTIC ENDOTHELIAL CELLS.

Bernd Steinbach
, Eugene Sprague
, Colin Schwartz
, Robert Nerem

Department of Medicine

Research output: Contribution to journal › Conference article › peer-review

1 Scopus citations

Abstract

Low density lipoprotein (LDL) transport and receptor-mediated metabolism are believed to be key factors in atherogenesis. The purpose of this study was to establish a link between LDL-internalization and steady, laminar hemodynamic shear stress by subjecting cultured bovine aortic endothelial cells (BAEC) to a known shear stress in a parallel-plate, channel flow device. The present studies establish that the application of a laminar, steady wall shear stress to confluent BAEC cultures enhances the internalization of **1**2**5I-LDL. This effect appears to not be dependent upon prior shear-induced changes in cell shape and orientation, nor is it limited to the time period during which cell geometry is changing.

Original language	English (US)
Pages (from-to)	191-194
Number of pages	4
Journal	American Society of Mechanical Engineers, Applied Mechanics Division, AMD
Volume	84
State	Published - 1987

ASJC Scopus subject areas

Mechanical Engineering

Cite this

INFLUENCE OF A STEADY LAMINAR SHEAR STRESS ON THE INTERNALIZATION OF LOW DENSITY LIPOPROTEINS BY CULTURED BOVINE AORTIC ENDOTHELIAL CELLS. / Steinbach, Bernd; Sprague, Eugene; Schwartz, Colin et al.
In: American Society of Mechanical Engineers, Applied Mechanics Division, AMD, Vol. 84, 1987, p. 191-194.

Research output: Contribution to journal › Conference article › peer-review

@article{cb4e41bfa21547b2b6b6ef49742b1825,

title = "INFLUENCE OF A STEADY LAMINAR SHEAR STRESS ON THE INTERNALIZATION OF LOW DENSITY LIPOPROTEINS BY CULTURED BOVINE AORTIC ENDOTHELIAL CELLS.",

abstract = "Low density lipoprotein (LDL) transport and receptor-mediated metabolism are believed to be key factors in atherogenesis. The purpose of this study was to establish a link between LDL-internalization and steady, laminar hemodynamic shear stress by subjecting cultured bovine aortic endothelial cells (BAEC) to a known shear stress in a parallel-plate, channel flow device. The present studies establish that the application of a laminar, steady wall shear stress to confluent BAEC cultures enhances the internalization of **1**2**5I-LDL. This effect appears to not be dependent upon prior shear-induced changes in cell shape and orientation, nor is it limited to the time period during which cell geometry is changing.",

author = "Bernd Steinbach and Eugene Sprague and Colin Schwartz and Robert Nerem",

year = "1987",

language = "English (US)",

volume = "84",

pages = "191--194",

journal = "American Society of Mechanical Engineers, Applied Mechanics Division, AMD",

issn = "0160-8835",

publisher = "American Society of Mechanical Engineers (ASME)",

}

TY - JOUR

T1 - INFLUENCE OF A STEADY LAMINAR SHEAR STRESS ON THE INTERNALIZATION OF LOW DENSITY LIPOPROTEINS BY CULTURED BOVINE AORTIC ENDOTHELIAL CELLS.

AU - Steinbach, Bernd

AU - Sprague, Eugene

AU - Schwartz, Colin

AU - Nerem, Robert

PY - 1987

Y1 - 1987

N2 - Low density lipoprotein (LDL) transport and receptor-mediated metabolism are believed to be key factors in atherogenesis. The purpose of this study was to establish a link between LDL-internalization and steady, laminar hemodynamic shear stress by subjecting cultured bovine aortic endothelial cells (BAEC) to a known shear stress in a parallel-plate, channel flow device. The present studies establish that the application of a laminar, steady wall shear stress to confluent BAEC cultures enhances the internalization of **1**2**5I-LDL. This effect appears to not be dependent upon prior shear-induced changes in cell shape and orientation, nor is it limited to the time period during which cell geometry is changing.

AB - Low density lipoprotein (LDL) transport and receptor-mediated metabolism are believed to be key factors in atherogenesis. The purpose of this study was to establish a link between LDL-internalization and steady, laminar hemodynamic shear stress by subjecting cultured bovine aortic endothelial cells (BAEC) to a known shear stress in a parallel-plate, channel flow device. The present studies establish that the application of a laminar, steady wall shear stress to confluent BAEC cultures enhances the internalization of **1**2**5I-LDL. This effect appears to not be dependent upon prior shear-induced changes in cell shape and orientation, nor is it limited to the time period during which cell geometry is changing.

UR - https://www.scopus.com/pages/publications/0023168792

UR - https://www.scopus.com/pages/publications/0023168792#tab=citedBy

M3 - Conference article

AN - SCOPUS:0023168792

SN - 0160-8835

VL - 84

SP - 191

EP - 194

JO - American Society of Mechanical Engineers, Applied Mechanics Division, AMD

JF - American Society of Mechanical Engineers, Applied Mechanics Division, AMD

ER -

INFLUENCE OF A STEADY LAMINAR SHEAR STRESS ON THE INTERNALIZATION OF LOW DENSITY LIPOPROTEINS BY CULTURED BOVINE AORTIC ENDOTHELIAL CELLS.

Abstract

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this